alexa The Production, Regulation and Extraction of Carotenoid
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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The Production, Regulation and Extraction of Carotenoids from Rhodosporidium toruloides

Jaslyn JL Lee and William WN Chen*

School of Chemical and Biomedical Engineering, Nanyang Technological University, Nanyang Drive, Singapore

*Corresponding Author:
William WN Chen
School of Chemical and Biomedical Engineering
Nanyang Technological University
62 Nanyang Drive
Singapore 63745
Tel: 6563162870
Fax: 6567947553
E-mail: [email protected]

Received date: March 15, 2016; Accepted date: May 07, 2016; Published date: May 12, 2016

Citation: Lee JJL, Chen WWN (2016) The Production, Regulation and Extraction of Carotenoids from Rhodosporidium toruloides. J Mol Genet Med 10:215. doi:10.4172/1747-0862.1000215

Copyright: © 2016 Lee JJL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Carotenoids are valuable pigments of commercial interest for various health benefits. There is rising demand for natural carotenoids from microorganisms, although the majority of industrially produced carotenoids are currently chemically synthesized. Rhodosporidium toruloides is oleaginous red yeast, which can produce large amounts of carotenoids and lipids simultaneously. It is also able to assimilate waste substrates as a carbon source. In this review we propose that Rhodosporidium toruloides's high lipid accumulating ability, is linked to its ability to also produce carotenoids. We provide details of the production and regulation of carotenoids and lipids biosynthesis in this yeast, which appear to be in sync. We attribute this to the fact that the simultaneous production of carotenoids and lipids is advantageous for the cells to maintain proper structure, function and membrane homeostasis. We also highlight the need for further developments in carotenoids extraction methods to advance microbial bioprocess technology. In addition, we provide information on recent carotenoids extraction technology using two phase media, developed in an engineered strain of Rhodosporidium toruloides. The in depth understanding of this yeast would help future developments to increase the yield and extraction of carotenoids and lipid.


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