The Progression of Serum Prorenin Concentration during PregnancyYukiko Mikami1*, Tatsuya Narita1, Yasushi Takai1, Kazunori Baba1, Hiroyuki Seki1 and Kikumi Matsuoka2
- *Corresponding Author:
- Yukiko Mikami
Department of Obstetrics and Gynecology
Saitama Medical Center, Saitama Medical University
1981Kamoda, Kawagoe, Saitama, 350-3550, Japan
E-mail: [email protected]
Received Date: June 13, 2014: Accepted Date: July 11, 2014: Published Date: July 20, 2014
Citation: Mikami Y, Narita T, Takai Y, Baba K, Seki H, et al. (2014) The Progression of Serum Prorenin Concentration during Pregnancy. J Hypertens 3:166. doi:10.4172/2167-1095.1000166
Copyright: © 2014 Mikami Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: An association between the renin-angiotensin system and the pathogenesis of pregnancy-induced hypertension has been reported. The prorenin receptor was discovered in 2002, and Wanatabe et al. reported that women with plasma soluble prorenin receptor concentrations above the 75th percentile at delivery had a significantly increased risk of preeclampsia. We evaluated serum prorenin concentrations during pregnancy, and we assessed the incidence of pregnancy-induced hypertension.
Methods: We measured serum prorenin concentrations in 430 pregnant women (565 samples). Regression analysis was performed to determine the associations between the serum prorenin level and maternal/neonatal complications.
Results: The serum prorenin concentration and gestational age had a positive correlation in non-pregnancyinduced hypertension in women with singleton pregnancies (Spearman rank-correlation coefficient, -0.215: p<0.0001). The serum prorenin concentration in women with multiple pregnancies was significantly higher than that in women with singleton pregnancies (multiple linear regression analysis, p<0.0001). Low prorenin levels in the third trimester (≤20.1 percentile) were significantly associated with pregnancy-induced hypertension (adjusted odds ratio, 18.16: 95% confidential interval, 1.95-412.41: p=0.0107).
Conclusion: The serum prorenin levels during pregnancy may be adversely correlated with the prorenin receptor, and low prorenin levels during late pregnancy were significantly associated with pregnancy-induced hypertension.