The Proportion of BNP Decline after Left Ventricular Assist Device Implantation Predicts Length of Survival after Surgery
- *Corresponding Author:
- Dr. Hirokazu Akashi MD
Department of Cardiothoracic Surgery
Columbia University Medical School, 650 West 168th Street
Room 807, New York, NY 10032, USA
E-mail: [email protected]
Received date: November 09, 2010; Accepted date: December 24, 2010; Published date: December 30, 2010
Citation: Akashi H, Kato TS, Shahzad K, Deng MC, Mancini DM, et al. (2010) The Proportion of BNP Decline after Left Ventricular Assist Device Implantation Predicts Length of Survival after Surgery. J Steroids Hormon Sci 1:103. doi:10.4172/2157-7536.1000103
Copyright: © 2010 Akashi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Differences in B-type natriuretic peptide (BNP) values before and after left ventricular assist device (LVAD) surgery were evaluated as a predictor of survival after the surgery. Background: The impact of reduction of pre-operative BNP values, following LVAD surgery, on post-operative survival in heart failure (HF) patients is not known. Methods: Among a total of 287 patients who underwent LVAD surgery at Columbia University Medical Center between 2000 and 2010, 72 patients who had plasma BNP measurements at both 1 week before and 1 month after surgery were enrolled. Patients were divided into 2 groups according to % change of BNP value through surgery (% BNP change): greater (group A) or less than (group B) the median % BNP change. Result: Neither pre-operative nor post-operative BNP values were significantly correlated with post-surgical survival. The % BNP change was significantly correlated with post-surgical survival. Clinical characteristics, laboratory examination, and hemodynamics before and after surgery were not different between the two groups. Group A patients showed significantly better survival at 100 and 200 post-surgical days compared to group B (86.1 % vs. 74.6 %, 80.6 % vs. 54.5%, p=0.0399, respectively). Conclusion: The % BNP change could predict survival after LVAD surgery.