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The Protective Effect of Hispanic Ethnicity on Chronic Obstructive Pulmonary Disease Mortality is Mitigated by Smoking Behavior | OMICS International | Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Research Article

The Protective Effect of Hispanic Ethnicity on Chronic Obstructive Pulmonary Disease Mortality is Mitigated by Smoking Behavior

Gregory L Kinney1*, Deborah SK Thomas2, Lisa Cicutto3, Lee S Newman4, Sharon Lutz5 and John E Hokanson1

1Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora Colorado, USA

2Department of Geography and Environmental Sciences, University of Colorado Denver, Denver Colorado, USA

3National Jewish Hospital and University of Colorado Denver, Denver Colorado, USA

4Department of Environmental Health, Colorado School of Public Health, University of Colorado Denver, Aurora Colorado, USA

5Department of Biostatistics, Colorado School of Public Health, University of Colorado Denver, Aurora Colorado, USA

*Corresponding Author:
Gregory L Kinney
Department of Epidemiology
Colorado School of Public Health
University of Colorado Denver, Aurora Colorado, USA
Tel: 303-724-4437
E-mail: [email protected]

Received date: October 20, 2014; Accepted date: November 20, 2014; Published date: November 25, 2014

Citation: Kinney GL, Thomas DSK, Cicutto L, Newman LS, Lutz S, et al. (2014) The Protective Effect of Hispanic Ethnicity on Chronic Obstructive Pulmonary Disease Mortality is Mitigated by Smoking Behavior. J Pulm Respir Med 4:220. doi:10.4172/2161-105X.1000220

Copyright: © 2014 Kinney GL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Rationale: Studies in Hispanic/Latino populations have shown ethnicity to be either a predictive or protective factor for COPD mortality and it is unclear whether this disagreement is attributable to ethnic differences in smoking rates, smoking behavior or differences in genetic susceptibility.

Objectives: This study will examine the role of smoking behavior as a means of explaining differences in risk for COPD mortality between Hispanics and non-Hispanic whites.

Methods: Participants were recruited into a cohort study from the San Luis Valley in Colorado beginning in the early 1980’s and followed for mortality until 2012. COPD and cardiovascular disease are often comorbid conditions and account for the competing risk of CVD in the analysis of COPD mortality. Mortality searches were conducted regularly and all ICD codes were collected for mortality event. Primary and secondary causes of each event were assessed using appropriate codes.

Results: Hispanic current smokers did not differ from NHW current smokers in years smoked (p=0.6) but Hispanic former smokers accumulated more years smoked compared to NHW former smokers (22 vs. 20, p=0.047). Hispanic ethnicity was significantly protective for COPD mortality adjusting for age, gender, pre-existing emphysema, hypertension and smoking status and accounting for the effect of CVD mortality (RR=0.58, 95% C.I. 0.34-0.99, p=0.035). Further adjustment for smoking behavior mitigated this effect.

Conclusions: The lower COPD mortality seen in Hispanic smokers may be due lower cumulative exposure to tobacco smoke. Thus, smoking behavior may play a key role in explaining differences in COPD mortality as they relate to Hispanic ethnicity.

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