alexa The Protein-Protein Interaction Networks of Dendritic S
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

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Research Article

The Protein-Protein Interaction Networks of Dendritic Spines in the Early Phase of Long-Term Potentiation

Anna L Proskura, Aleksander S Ratushnyak, Tatyana A Zapara*

Design Technological Institute of Digital Techniques SB RAS, Novosibirsk, Russia

*Corresponding Author:
Tatyana A Zapara
Design Technological Institute of Digital Techniques SB RAS
Novosibirsk, Russia
Tel: +7 383 3308918
E-mail: [email protected]

Received Date: December 20, 2013; Accepted Date: January 08, 2014; Published Date: January 10, 2014

Citation: Proskura AL, Ratushnyak AS, Zapara TA (2014) The Protein-Protein Interaction Networks of Dendritic Spines in the Early Phase of Long-Term Potentiation. J Comput Sci Syst Biol 7:040-044. doi: 10.4172/jcsb.1000136

Copyright: © 2014 Proskura AL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The neuron is a basic element of brain networks. Changes of nerve cell excitability, the conduction of excitation, synaptic memory-forming in the case of the temporal coincidence of synaptic events are the obvious functions of the neuron - element of brain networks. The implementation of the neuron function depends on actions of its numerous molecular systems. The generalization of the complex processes of emergence of synaptic memory, that occur even in separate neuronal compartments, without special tools is a difficult, if at all possible, task. A technology that combines the creation of databases (elements and their relationships) with a visual representation in the form of networks facilitates this process. The developed protein-protein interaction network in dendritic spines of hippocampal pyramidal neurons facilitates the synthesis of numerous experimental data in conceptual knowledge about the principles and molecular mechanisms of neurons functioning.


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