The Pursuit of a HIV Vaccine Ã¢ÂÂ Trials, Challenges and Strategies
Nageswara Rao Alla*
Department of Pulmonary Allergy and Critical Care medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, USA
- *Corresponding Author:
- Nageswara Rao Alla
Division of Pulmonary
Allergy and Critical Care Medicine
University of Pittsburgh, Pittsburgh
Pennsylvania, PA-15213, USA
Tel: 267 467 5439
E-mail: [email protected]
Received Date: March 04, 2014; Accepted Date: April 11, 2014; Published Date: April 25, 2014
Citation: Nageswara Rao A (2014) The Pursuit of a HIV Vaccine – Trials, Challenges and Strategies. J AIDS Clin Res 5:298. doi:10.4172/2155-6113.1000298
Copyright: © 2014 Nageswara Rao A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The search for a HIV vaccine that can elicit potent, long lasting and broad immune responses to both prevent acquisition of infection and control viral replication has been going on for over two decades. The modest success of the RV144 vaccine efficacy trial and isolation of broadly neutralizing antibodies capable of neutralizing different HIV strains has reinvigorated research in antibody based vaccine design and development strategies. This review will discuss the efficacy trials conducted to date, lessons learned from the trials, challenges and current strategies being pursued in the HIV vaccine field.