alexa The Ratio of Glycated Albumin to HbA1c is Correlated with Diabetes Duration According to Decreases in Insulin Secretion in Patients with Autoimmune Type 1 Diabetes and Type 2 Diabetes
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Research Article

The Ratio of Glycated Albumin to HbA1c is Correlated with Diabetes Duration According to Decreases in Insulin Secretion in Patients with Autoimmune Type 1 Diabetes and Type 2 Diabetes

Hirata T1,2, Saisho Y3, Morimoto J1, Kasayama S4, Koga M5* and Maruyama T1

1Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan

2Foundation for Biomedical Research and Innovation, Hyogo, Japan

3Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

4Department of Medicine, Nissay Hospital, Osaka, Japan

5Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan

*Corresponding Author:
Masafumi Koga
Department of Internal Medicine
Kawanishi City Hospital, 5-21-1 Higashi-Uneno
Kawanishi 666-0915, Hyogo, Japan
E-mail: [email protected]

Received date: July 31, 2013; Accepted date:August 08, 2013; Published date: August 10, 2013

Citation: Hirata T, Saisho Y, Morimoto J, Kasayama S, Koga M, et al. (2013) The Ratio of Glycated Albumin to HbA1c is Correlated with Diabetes Duration According to Decreases in Insulin Secretion in Patients with Autoimmune Type 1 Diabetes and Type 2 Diabetes. J Genet Syndr Gene Ther 4:168. doi:10.4172/2157-7412.1000168

Copyright: © 2013 Hirata T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glycated albumin (GA) is a marker of glycemic control that reflects postprandial plasma glucose levels and glycemic excursions better than HbA1c. However, no reports have examined correlations between diabetes duration and the ratio of glycated albumin to HbA1c (GA/HbA1c ratio) in patients with autoimmune type 1 diabetes (T1AD) or type 2 diabetes (T2D). We conducted a cross-sectional study involving 219 patients with T1AD and 141 patients with T2D. We evaluated correlations between diabetes duration, the GA/HbA1c ratio and fasting serum C-peptide immunoreactivity (CPR), index of insulin secretion capacity. The GA/HbA1c ratio was significantly correlated with diabetes duration in both T1AD and T2D patients (T1AD; R=0.139, p<0.001, T2D; R=0.340, p<0.001). Fasting serum CPR was inversely correlated with diabetes duration (T1AD: R=-0.280, p<0.001; T2D: R=-0.349, p<0.001) as well as the GA/HbA1c ratio (T1AD: R=-0.240, p<0.001; T2D: R=-0.378, p<0.001) in both T1AD and T2D patients. We firstly reported that the GA/HbA1c ratio was positively correlated with diabetes duration in both T1AD and T2D patients. Insulin secretion capacity might influence this relationship.

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