alexa The Relationship between Leukocyte Counts and Venous Th
ISSN: 0974-8369

Biology and Medicine
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Research Article

The Relationship between Leukocyte Counts and Venous Thromboembolism: Results from RETROVE Study

Noelia Vilalta1*, Miquel Vázquez-Santiago1,2, Biel Cuevas1, Raquel Macho1, Angel Remacha3, Marina Carrasco1, José Mateo1, Juan Millón1, José Manuel Soria2 and Juan Carlos Souto1

1Unitat d’Hemostàsia i Trombosi, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167, Barcelona, Spain

2Unitat de Genòmica i Malalties Complexes, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167, Barcelona, Spain

3Departament d’Hematologia, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167, Barcelona, Spain

*Corresponding Author:
Noelia Vilalta
Unitat d’Hemostàsia i Trombosi
Hospital de la Santa Creu i Sant Pau
Sant Quintí 89, Barcelona, Spain 08026
Tel: +34 9335537151
Fax: +34 9335537153
E-mail: [email protected]

Received Date: May 31, 2017; Accepted Date: June 20, 2017; Published Date: June 27, 2017

Citation: Vilalta N, Vázquez-Santiago M, Cuevas B, Macho R, Remacha A, et al. (2017) The Relationship between Leukocyte Counts and Venous Thromboembolism: Results from RETROVE Study. Biol Med (Aligarh) 9: 400. doi:10.4172/0974-8369.1000400

Copyright: © 2017 Vilalta N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: Different studies have shown a possible increased risk of venous thromboembolism (VTE) and arterial thrombosis in patients with an increased leukocyte count. The underlying mechanisms are not completely understood, but they could partly be explained by the role that white blood cells play in inflammation. Our objective is to investigate investigated the relationship between leukocyte counts and VTE. Material and methods: Analyses were performed in 400 patients and 400 control subjects of the RETROVE (Riesgo de Enfermedad TROmboembólica VEnosa) Study. To evaluate the odds ratio (OR) for VTE of leukocyte counts we used an unconditional logistic regression analysis taking into account the confounders. Results: We observed more spontaneous (273, 68.3%) than non–spontaneous (127, 31.8%) VTE. Monocyte counts showed a strong association with thrombosis risk: For the 90th percentile in the controls (>0.7 × 109/L), the OR of VTE and its 95% confidence intervals are 2.1 (1.4-3.3). A highly significant relation between high monocyte counts and spontaneous VTE was found. Conclusion: We confirmed a strong association between high monocyte counts and past VTE. High monocyte counts (even within the clinical reference range) could constitute a risk factor for VTE.


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