The Relationship between Serum 25(OH)D, PTH and Calculated HOMA-IR in Overweight Elderly PatientsHongfeng Jiang* and Shaorong Peng
Gerontology Department, Puai hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province,430033, China
- *Corresponding Author:
- Jiang H
Gerontology Department, Puai hospital
Tongji Medical College
Huazhong University of Science and Technology
Wuhan, Hubei Province,430033, China
Tel: +86 027 68831380
E-mail: [email protected]
Received date: August 16, 2015 Accepted date: January 27, 2016 Published date: February 03, 2016
Citation: Jiang H, Peng S (2016) The Relationship between Serum 25(OH)D, PTH and Calculated HOMA-IR in Overweight Elderly Patients. Aging Sci 4:146. doi: 10.4172/2329-8847.1000146
Copyright: © 2016 Jiang H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Vitamin D deficiency or insufficiency was commonly found among adults and particularly overweight elderly patients. It’s controversial on the physiological roles of vitamin D and parathyroid hormone (PTH) in metabolic diseases. We explored the relationship between serum 25-hydroxyvitamin D [25(OH)D], PTH and homeostasis model of assessment for insulin resistance index (HOMA-IR) in overweight elderly patients. Methods: 162 elderly overweight patients were included as the overweight group, and 80 normal-weight elderly in-patients were enrolled as the control group. The concentrations of 25(OH)D, PTH, blood calcium (CA), fasting blood glucose (FBG), and fasting blood insulin (FINS) were determined and HOMA-IR were calculated. Results: The occurrence rate of vitamin D deficiency or insufficiency, primary hypertension, diabetes mellitus type 2 ando steoporosis in the overweight group was significantly higher than that in the control group (p<0.05). The levels of serum PTH, systolic blood pressure (SBP) , diastolic blood pressure (DBP), waist circumference and HOME-IR of the overweight group were significantly higher than that of control group, while serum 25(OH)D and blood calcium were significantly lower (p<0.05). The difference on serum phosphate levels was not significant. Body Mass Index (BMI) was positively correlated with HOMA-IR, r=0.291(F=22.167ï¼Âp<0.001); Serum 25(OH)D was negatively correlated with HOMA-IR, r=-0.272 (F=19.224ï¼Âp<0.001); Serum PTH was positively correlated with HOMA-IR, r=0.205 (F=10.4883, p=0.001). Stepwise multiple regression analysis was applied and there was a correlation between HOMA-IR and BMI, 25(OH) D (r=0.353, F=16.984, p<0.001). Conclusion: Vitamin D deficiency or insufficiency and the increase of BMI were significantly associated with insulin resistance in overweight elderly patients.