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The Relevance of Cytokines for Mucosal Immunity Induced By Dietary Vanadium in the Intestine of Broilers | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

The Relevance of Cytokines for Mucosal Immunity Induced By Dietary Vanadium in the Intestine of Broilers

Yuanxin Deng, Hengmin Cui*, Xi Peng, Jing Fang, Zhicai Zuo, Kangping Wang, Wei Cui and Bangyuan Wu

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China

*Corresponding Author:
Dr. Hengmin Cui
Professor, College of Veterinary Medicine
Sichuan Agricultural University, Yaan
Sichuan 625014, China
Tel: +86 13608264628
Fax: +86 0835 2882340
E-mail: [email protected], [email protected]

Received date: March 02, 2012; Accepted date: April 04, 2012; Published date: April 06, 2012

Citation: Deng Y, Cui H, Peng X, Fang J, Zuo Z, et al. (2012) The Relevance of Cytokines for Mucosal Immunity Induced By Dietary Vanadium in the Intestine of Broilers. Medchem 2:114. doi:10.4172/2161-0444.1000114

Copyright: © 2012 Deng Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cytokines are key regulators of the immune system that shapes both the innate and adaptive immune responses. Present knowledge allows a deeper understanding of the cytokine network and their complex roles in the development of immune responses. The purpose of this study was to examine the effect of dietary vanadium on the contents of cytokines such as interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in the mucosa of different parts of intestines (duodenum, jejunum and ileum) by Enzyme-Linked Immunosorbent Assay (ELISA). A total of 420 one-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet (control diet) or the same basal diet supplemented with 5 mg/kg, 15 mg/kg, 30 mg/kg, 45 mg/kg and 60 mg/kg vanadium in the form of ammonium metavanadate, respectively. During the experimental period of 42 days, the results showed that the IL-2, IL-10, IFN-γ and TNF-α contents were significantly lower (p<0.05 or p<0.01) in the 30 mg/kg, 45 mg/kg and 60 mg/kg groups than those in the control group, and the IL-6 contents were significantly decreased (p<0.05 or p<0.01) mainly in the 45 mg/kg and 60 mg/kg groups in comparison with those of the control group. It was concluded that dietary vanadium in excess of 30 mg/kg significantly reduced the contents of above cytokines in the intestinal mucosa of broilers, which could impact the function of intestinal mucosal immunity by affecting the pathways that reduced the lymphocyte population and / or lymphocyte activation.