Objective. The experimental investigations on the teeth of rats for determining the prophylaxis influence of the
glutamic acid on the level of dental (teeth) fluorosis were made. Have been studied both clinical and histological
conditions (picture) of teeth of experimental animals.
We made experiment on 60 rats with 30-50 gr by weight. The animals have been divided into 3 groups 20 rats in
each group. The I groups (control) the rats which were on a usual vivarium ration and received water with the
contents of fluorine 0,30-0,45 mg/l; II group (comparision) rats receiving water with the contents of fluorine 15
mg/l; III group Â– (main group) Â– the animals received both water with the contents of fluorine 15 mg /l and 1%
solution of glutamic acid 2 times per a week intra orally. Histological investigations have been made on sections
of ratÂ’s teeth, which were painted (colored) with hemotoxilin Â–eozine, thionine.
Results. On incisors of rats receiving water with the contents 15 mg/l of fluorine at 4-5 weeks the area (zone) of
depigmentation characteristic for dental fluorosis has appeared. Microscopically was observed hypoplasia, enamel
prisms have both crimped and indirect courses. The results of these were the infringement of Sroger line and
sometimes its abcence. In group of rats receiving simultaneously water with high concentrations of fluorine and
1% solution of glutamic acid similar both clinical and hystochemikal changes were not occurred (marked).
Conclusion. The glutamic acid prevented teeth fluorosis because of neutralization of a fluoric intoxiation (high
level of fluorine).