alexa The Role of Anti-Helicobacter Pylori Therapy in Remission Induction of Primary Gastric Lymphoma by Analysis of Microsatellite Instability | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

The Role of Anti-Helicobacter Pylori Therapy in Remission Induction of Primary Gastric Lymphoma by Analysis of Microsatellite Instability

Azza M Ezz Eldin1*, Enas Reda Alkareemy2, Ashraf Zedan3, Ahmed Abdel Warith4, Amen H. Zaky3 and A Khalifa5

1Clinical pathology department, Assuit University, Egypt

2Internal Medicine department, Gastroenterology and endoscopy unit, Assuit, Egypt

3Medical Oncology department South Egypt Cancer Institute, Egypt

4Medical Oncology department, National cancer Institute, Cairo, Egypt

5Oncology Department, Assiut University, Egypt

*Corresponding Author:
M Ezz Eldin
Egypt, Clinical pathology department
Assiut University Egypt
Tel: 0020101918207
E-mail: [email protected]

Received date: October 04, 2010; Accepted date: October 29, 2010; Published date: October 29, 2010

Citation: Ezz Eldin AM, Alkareemy ER, Zedan A, Abdel Warith A, Zaky AH, et al. (2010) The Role of Anti-Helicobacter Pylori Therapy in Remission Induction of Primary Gastric Lymphoma by Analysis of Microsatellite Instability. J Carcinogene Mutagene 1:107. doi: 10.4172/2157-2518.1000107

Copyright: © 2010 Ezz Eldin AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The molecular mechanism associated with remission of primary gastric lymphoma post helicobacter pylori eradication is still unclear.
 
Aim of the study: to evaluate Microsatellite (MSI) instability at markers adjacent to Chromosomal loci involved in primary gastric lymphoma in relation to helicobacter eradication therapy.
 
Methods: 107 primary gastric lymphoma patients included 30 low grade Mucosa Associated Lymphoid Tissue
Gastric lymphoma (MALT), 36 Diffuse large gastric lymphoma with MALT component (MALTDLBCL) and 41 DLBCL gastric lymphoma (DLBCL) were treated with anti Helicobacter pylori therapy as fi rst line treatment and to asses for Microsatellite instability (MSI)
 
Results: the incidence of complete remission post helicobacter pylori eradication was higher in Low grade MALT in comparison to MALTDLBCL and denovo DLBCL. The incidence of MSI is decrease post helicobacter pylori eradication in all subtypes Conclusion: Remission of gastric lymphoma post Helicobacter eradication may associate with correction of MSI level.
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