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ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Review Article

The Role of Arsenic on Skin Diseases, Hair Fall and Inflammation: An Immunological Review and Case Studies

Wahida Khan Chowdhury1, AbidaTisha2, Sharmim Akter3, Shah Mehedi Bin Zahur4, Nahid Hasan2, Ahmed Shohrawar Mahadi2, Fazla Rabby SM2, Mohd Mohabbulla Mohib2, Mohd Abu Taher Sagor2* and Sarif Mohiuddin5

1Department of Dermatology, Shahabuddin Medical College and Hospital, Bangladesh

2Department of Pharmaceutical Sciences, School of Life Sciences, North South University, Bangladesh

3Department of Medicine, Dhaka Central International Medical College and Hospital, Bangladesh

4Infectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh

5Department of Anatomy and Physiology, Pioneer Dental College and Hospital, Bangladesh

*Corresponding Author:
Md Abu Taher Sagor
Department of Pharmaceutical Sciences
North South University, Dhaka-1229, Bangladesh
Tel: +8801719130130
Email: [email protected]

Received Date: February 09,2017; Accepted Date: February 18,2017; Published Date: February 24,2017

Citation: Chowdhury WK, Tisha A, Akter S, Zahur SMB, Hasan N, et al. (2017) The Role of Arsenic on Skin Diseases, Hair Fall and Inflammation: An Immunological Review and Case Studies. J Clin Exp Dermatol Res 8:384. doi: 10.4172/2155-9554.1000384

Copyright: © 2017 Chowdhury WK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this recent era, occupational and accidental spills have been dramatically increased since last few decades due to globalization throughout the world. Concurrently, the concerns on health issues are being a burning question to the all corporate as well as health care professional personnel. Currently, arsenic and arsenic related problems have drawn a great attention as this compound acts not only as slow poison but also works as beneficial molecule in the treatment of some diseases. Laboratory animals showed several dysfunctions including keratinocytes dysfunctions, loss of hair and most importantly inflammation. Arsenic-mediated cell stress/oxidative stress also plays a major role in the development of multiple pathways like JNK, AP-1, PKC and caspase which further either lead to apoptosis or cancer. Countries like Bangladesh, India, Mexico, Chile and China are in great risk and the human from these areas are losing their lives due to chronic arsenic exposures. Therefore, this study will try to explain the proposed molecular mechanisms of arsenic-induced skin diseases, hair fall and inflammation. Finally, a possible treatment approach would be disclosed against arsenic-mediated disorders.

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