alexa The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD | OMICS International | Abstract
ISSN: 2167-1044

Journal of Depression and Anxiety
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Review Article

The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD

Alexander Neumeister1*, Stefani Corsi-Travali2 and Christopher R. Green2
1Molecular Imaging Program, Department of Psychiatry and Radiology, New York University School of Medicine, New York, USA
2Steven and Alexandra Cohen Veterans Center for the Study of Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University Langone Medical Center, New York, USA
*Corresponding Author : Alexander Neumeister
Director, Molecular Imaging Program
Department of Psychiatry and Radiology
New York University School of Medicine
One Park Avenue, 8th Floor
Room 225, New York-10016, USA
Tel: (646) 754-4827
E-mail: [email protected]
Received September 09, 2013; Accepted September 30, 2013; Published October 04, 2013
Citation: Green CR, Corsi-Travali S, Neumeister A (2013) The Role of BDNFTrkB Signaling in the Pathogenesis of PTSD. J Depress Anxiety S4:006. doi:10.4172/2167-1044.S4-006
Copyright: © 2013 Neumeister A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Post traumatic Stress Disorder (PTSD) is a prevalent, chronic, and disabling anxiety disorder that may develop following exposure to a traumatic event. The majority of individuals with PTSD often have comorbid psychiatric conditions such as major depression, generalized anxiety disorder, and substance use disorders, and are at increased risk for suicide. Despite the public health significance of PTSD, relatively little is known about the etiology or pathophysiology of this disorder, and pharmacotherapy development to date has been largely opportunistic instead of mechanismbased. One promising target for modulation is Tropomyosin Receptor Kinase B (TrkB), the receptor for Brain-Derived Neurotrophic Factor (BDNF), a signaling pathway important for neuronal plasticity, survival, and growth. The following
discusses how genetic and environmental alterations to this signaling pathway may contribute to  anatomical and functional changes in the hippocampus, amygdala, anterior cingulate cortex,  ventromedial prefrontal cortex, and the nucleus accumbens. Changes in these brain regions may in turn contribute to the predisposition to or maintenance of some of the clinical manifestations of PTSD, including intrusive memories, hyperarousal, increased fear, and emotional numbing.

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