alexa The Role of CD4+ T cells in the Development of an Efficacious HIV Vaccine | OMICS International
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Role of CD4+ T cells in the Development of an Efficacious HIV Vaccine

Haitao Liu1,2, Wei Shen1, Jiayi Shu1 and Xia Jin1*
1Viral Disease and Vaccine Translational Research Unit & Vaccine Centre, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
2School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China
Corresponding Author : Xia Jin, M.D., Ph.D
Professor, Principal Investigator
Viral Disease and Vaccine Translational Research Unit
Institut Pasteur of Shanghai
Chinese Academy of Sciences
320 Yueyang Road, Shanghai 200031, China
E-mail: [email protected]
Received: June 15 2015 Accepted: August 21, 2015 Published: August 28, 2015
Citation: Liu H, Shen W, Shu J, Jin X (2015) The Role of CD4+ T cells in the Development of an Efficacious HIV Vaccine. J Clin Cell Immunol 6:350. doi:10.4172/2155-9899.1000350
Copyright: © 2015 Liu H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

HIV infection has caused serious public health disaster during the past three decades. The rapid discovery of antiretroviral drugs and the implementation of combination antiretroviral therapy in many countries over the past two decades have led to a marked decrease in HIV-associated mortality and morbidity. However, the antiretroviral therapy alone has been unable to eradicate the virus from HIV-infected individuals. To reduce the incidence of HIV infection on a global scale, vaccine is still the most cost-effective method. Due in part to the lack of a comprehensive understanding of immune correlates of protection, an effective HIV vaccine has not yet been developed. Since CD4+ T cells play a central role in orchestrating various arms of immune responses, vaccines that mobilize CD4+ T cells should help to elicit desired immune responses for the prevention of HIV infection. The current knowledge on subsets of CD4+ T cells and their perceived roles in mediation and formation of post-vaccination protective immunity are discussed.

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