The Role of GroE Chaperonins in Developing Biocatalysts for Biofuel and
Peng-Fei Xia1, Timothy Lee Turner2 and Lahiru N Jayakody3*
1School of Environmental Sciences and Engineering, Shandong University, 27 Shanda Nanlu, Jinan, 250100, P.R. China
2Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA
3National Bioenergy Center, National Renewable Energy Lab, 15013 Denver West Parkway, Golden, CO, 80401, USA
- *Corresponding Author:
- Lahiru N Jayakody
National Bioenergy Center, National Renewable Energy Lab
15013 Denver West Parkway, Golden, CO, 80401 USA
E-mail: [email protected]
Received Date: September 12, 2016; Accepted Date: October 31, 2016; Published Date: November 03, 2016
Citation: Xia PF, Turner TL, Jayakody LN (2016) The Role of GroE Chaperonins in Developing Biocatalysts for Biofuel and Chemical Production. Enz Eng 5:153. doi: 10.4172/2329-6674.1000153
Copyright: © 2016 Xia PF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
As the need and interest for producing renewable biofuels and biochemical has grown, new avenues to improve product yields and productivity have been explored. Specifically, improving the tolerance of host microbes towards stressors, such as heat shock or the presence of harmful solvents, has been an especially important route to improve industrial-scale chemical production. In this review, we discuss recent advances in microbial engineering for renewable chemical production through the introduction and expression of chaperonins, especially the bacterial GroE complex. The GroE complex provides a closed-off environment and allows vital proteins to enter and engage in post-translational folding or refolding in a more-ideal environment, allowing the microbe to possess increased survival rates in low/high temperatures or in high concentrations of otherwise harmful end-products. Overall, we highlighted how chaperonin systems such as the GroE complex could have many industrially-relevant uses in the coming years.