Review Article
The Role of Inflammatory Cytokines in the Pathogenesis of Cerebral Palsy
Hua Di1, Qi He1, Yingye Liao1, Bill Kalionis2 and Xiantao Tai1*1School of Acupuncture, Massage and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, PR China
2Department of Perinatal Medicine Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynecology, Royal Women’s Hospital, Parkville3052, Australia
- *Corresponding Author:
- Xiantao Tai
School of Acupuncture, Massage and Rehabilitation
Yunnan University of Traditional Chinese Medicine
Kunming 650500, Yunnan, PR China
Tel: +86-871-65918024
Fax: +86-871- 65918153
E-mail: [email protected]
Received Date: January 31, 2016; Accepted Date: Feburary 15, 2016; Published Date: Feburary 17, 2016
Citation: Di H, He Q, Liao Y, Kalionis B, Tai X (2016) The Role of Inflammatory Cytokines in the Pathogenesis of Cerebral Palsy. Gynecol Obstet(Sunnyvale) 6:360. doi: 10.4172/2161-0932.1000360
Copyright: © 2016 Di H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Cerebral palsy (CP) refers to a group of major neurodevelopmental disorders that affect movement and posture. CP results from damage to the developing brain during pregnancy, or shortly after birth and a growing body of research suggests that inflammation may play a vital role in its development. Here, we review the contribution of inflammatory cytokines (such as NF-κ B, IL-6, IL-8, TNF-α ) to the mechanism of CP. Individual cytokines play specific roles in pathogenesis of CP but they also interact with each other and form a complex network of inflammatory reaction-regulating systems. Investigating the mechanisms of action of inflammatory cytokines in the development of CP may contribute not only to our understanding of the pathogenesis of CP but may also lead to more rational and effective intervention strategies.
