alexa The Role of Ischemia-Reperfusion Injury in Reconstructive Transplantation | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
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Review Article

The Role of Ischemia-Reperfusion Injury in Reconstructive Transplantation

Saami Khalifian, Damon S Cooney, WP Andrew Lee and Gerald Brandacher*

Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA

*Corresponding Author:
Gerald Brandacher
Scientific Director
Reconstructive Transplantation Program
Department of Plastic and Reconstructive Surgery
Johns Hopkins University School of Medicine
Ross Research Building 749D, 720 Rutland Avenue
Baltimore, MD21205, USA
Tel: (443) 287-6679
Fax: (410) 614-1296
E-mail: [email protected]

Received Date: May 03, 2013; Accepted Date: June 07, 2013; Published Date: June 10, 2013

Citation: Khalifian S, Cooney DS, Andrew Lee WP, Brandacher G (2013) The Role of Ischemia-Reperfusion Injury in Reconstructive Transplantation. J Transplant Technol Res S3: 004. doi: 10.4172/2161-0991.S3-004

Copyright: © 2013 Khalifian S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Reconstructive transplantation, also referred to as vascularized composite allotransplantation (VCA), has rapidly emerged as a viable approach to repairing complex tissue defects. Over the past 20 years, major advances have been made in the field of VCA allowing for successful transplantation of over 150 hand/forearm/arm, larynx, trachea, abdominal wall, vascularized knee, and facial transplants with encouraging outcomes. These innovations have currently outpaced the scientific community’s ability to fully address certain immunological and clinical challenges. The literature on ischemia-reperfusion injury (IRI) in VCA is limited and mechanistic questions remain. Specifically, the role IRI may play in acute rejection, the progression towards chronic rejection, or immune regulation and tolerance induction has only been partially or indirectly addressed. Hence, much of what we understand regarding IRI in VCA is extrapolated from research in solid organ transplantation (SOT). This review will address the role of IRI in VCA, first outlining its impact on SOT, it’s effects on the immune system and allograft rejection, as well as the clinical implications that IRI has for VCA outcomes.

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