alexa The Role of Lymphatic Vessels in Renal Injury | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Role of Lymphatic Vessels in Renal Injury

Harald Seeger1,2 and Stephan Segerer1,2*
1Division of Nephrology, University Hospital, Zurich, Switzerland
2Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland
Corresponding Author : Stephan Segerer
Division of Nephrology
University Hospital Zurich
Rämistr. 100, 8091 Zurich, Switzerland
Tel: +41 (0) 44 2559698
Fax: +41 (0) 44 2554593
E-mail: [email protected]
Received June 23, 2014; Accepted August 26, 2014; Published September 03, 2014
Citation: Seeger H, Segerer S (2014) The Role of Lymphatic Vessels in Renal Injury. J Clin Cell Immunol 5:255. doi:10.4172/2155-9899.1000255
Copyright: © 2014 Seeger H et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Progressive kidney diseases are characterized by the recruitment of inflammatory cells to the tubulointerstitium, tubular atrophy and fibrosis. The number of lymphatic vessels increases in the interstitium during this process (i.e. neolymphangiogenesis). Here we will describe the current evidence for neolymphangiogenesis during renal injury, summarize the major factors involved and discuss the functional consequences. Data are emerging that central profibrotic players like TGF-β also mediate the release of lymphangiogenic factors such as VEGF-C and VEGF-D in the kidney. Furthermore, in other organs activation of TGF-β by VEGF-C has been described. The complex interactions of profibrotic and lymphangiogenic factors might explain why lymphangiogenesis was found to be associated with fibrosis in some models, but a reduction in fibrosis in others. It is likely that the functional consequences of lymphangiogenesis depend on the stage of the disease course and the microenvironment where it takes place. Studies are needed where lymphangiogenesis is switched on or off at defined time points. However such data are not yet available in models of renal diseases.

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