alexa The Role of Melatonin in Improving Clinical Responses of Chemotherapy in Solid Cancer Patients: A Systematic Review | OMICS International| Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Mini Review   
  • J Cancer Sci Ther/Vol.11.1 020(2019),
  • DOI: 10.4172/1948-5956.1000577

The Role of Melatonin in Improving Clinical Responses of Chemotherapy in Solid Cancer Patients: A Systematic Review

Diani Kartini1*, Sonar Soni Panigoro1, Muchlis Ramli1, Rianto Setiabudy2 and Akmal Taher3
1Oncology Division, Surgery Department, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
2Faculty of Medicine, Pharmacology and Therapeutics Department, Universitas Indonesia, Jakarta, Indonesia
3Urology Department, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
*Corresponding Author : Diani Kartini, Oncology Division, Surgery Department, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia, Tel: +628122684919, Email: [email protected]

Received Date: Jan 05, 2019 / Accepted Date: Jan 23, 2019 / Published Date: Jan 25, 2019

Abstract

Background: Melatonin is known as a potent antioxidant. It also has other roles in modulating immune system and inhibiting proliferation, depending on the dose given. This agent has been used widely as a supplementation in cancer patients. However, effect of this antioxidant towards the efficacy of various therapeutic modalities in cancer, including chemotherapy, remains unclear.

Objective: This systematic review aims to know effect of melatonin as an adjuvant therapy towards chemotherapy response in solid cancer patients.

Methods: We reviewed articles systematically from 8 databases including Pubmed, EBSCO, Cochrane, ClinicalKey, Proquest, ScienceDirect, Scopus, and Wiley Online Library. Keywords used in literature searching were cancer and all similar terms, melatonin, chemotherapy, and response. We used limitations to narrow the result. We included clinical trials that evaluated clinical response of chemotherapy in solid cancer patients. Studies were reviewed by two authors using OXFORD RCT appraisal sheets.

Results: The results showed improved clinical response associated with chemotherapy plus melatonin treatment. Two out of eight studies were not statistically significant (p>0.05). There was high risk of bias in all of the studies regarding randomization process, allocation concealment, intention-to-treat principal, and blinding.

Conclusion: Melatonin has positive effect in improving chemotherapy response in solid cancer patients. Regarding the lack of methodological validation in prior studies, larger and well-designed studies are needed in the future.

Keywords: Melatonin; Cancer; Solid; Chemotherapy; Clinical response

Citation: Kartini D, Panigoro SS, Ramli M, Setiabudy R, Taher A (2019) The Role of Melatonin in Improving Clinical Responses of Chemotherapy in Solid Cancer Patients: A Systematic Review. J Cancer Sci Ther 11:020-024. Doi: 10.4172/1948-5956.1000577

Copyright: © 2019 Kartini D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Relevant Topics
Article Usage
  • Total views: 447
  • [From(publication date): 0-0 - Jul 20, 2019]
  • Breakdown by view type
  • HTML page views: 400
  • PDF downloads: 47
Leave Your Message 24x7
Top