alexa The Role of miR-1 in the Heart: From Cardiac Morphogenesis to Physiological Function
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Review Article

The Role of miR-1 in the Heart: From Cardiac Morphogenesis to Physiological Function

Fangfei Deng1-3, Xinran Xu1 and Yi-Han Chen1-4*

1Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China, Tongji University, Shanghai 200120, China

2Institute of Medical Genetics, Tongji University, Shanghai 200092, China

3Department of Cardiology, East Hospital, Tongji University, Shanghai 200120, China

4Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China

*Corresponding Author:
Yi-Han Chen
Key Laboratory of Basic Research in Cardiology
of the Ministry of Education of China
Tongji University, No.150 Jimo Road
Shanghai 200120, China
Tel: +086-21-58766224
Fax: +086-21-65989086
E-mail: [email protected]

Received January 02, 2014; Accepted January 26, 2014; Published January 31, 2014

Citation: Deng F, Xu X, Chen YH (2014) The Role of miR-1 in the Heart: From Cardiac Morphogenesis to Physiological Function. Human Genet Embryol 4:119. doi: 10.4172/2161-0436.1000119

Copyright: © 2014 Deng F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Heart is pumping throughout life of animals ever since embryogenesis. The mammalian heart consists of four chambers along with specialized myocardial system for electrical conduction and force production, which guarantees the heart to pump efficiently. miR-1, the cardiac specific mi RNA, is suggested to play essential roles in cardiogenesis and in regulating physiological function of heart. During early stage of cardio genesis, miR-1 promotes cardiac mesoderm induction. In the subsequent morphogenesis, miR-1 controls cell fate of various lineages and the balance between proliferation and differentiation so that cardiac chambers could develop normally. In postnatal life, miR-1 modulates atrioventricular and ventricular conduction at multiple levels and contributes to the formation of organized sarcomere. Advance in the role miR-1 plays in cardiac biological processes have put new perspectives on mechanisms of heart diseases.

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