The Role of miR-1 in the Heart: From Cardiac Morphogenesis to Physiological FunctionFangfei Deng1-3, Xinran Xu1 and Yi-Han Chen1-4*
- *Corresponding Author:
- Yi-Han Chen
Key Laboratory of Basic Research in Cardiology
of the Ministry of Education of China
Tongji University, No.150 Jimo Road
Shanghai 200120, China
E-mail: [email protected]
Received January 02, 2014; Accepted January 26, 2014; Published January 31, 2014
Citation: Deng F, Xu X, Chen YH (2014) The Role of miR-1 in the Heart: From Cardiac Morphogenesis to Physiological Function. Human Genet Embryol 4:119. doi: 10.4172/2161-0436.1000119
Copyright: © 2014 Deng F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Heart is pumping throughout life of animals ever since embryogenesis. The mammalian heart consists of four chambers along with specialized myocardial system for electrical conduction and force production, which guarantees the heart to pump efficiently. miR-1, the cardiac specific mi RNA, is suggested to play essential roles in cardiogenesis and in regulating physiological function of heart. During early stage of cardio genesis, miR-1 promotes cardiac mesoderm induction. In the subsequent morphogenesis, miR-1 controls cell fate of various lineages and the balance between proliferation and differentiation so that cardiac chambers could develop normally. In postnatal life, miR-1 modulates atrioventricular and ventricular conduction at multiple levels and contributes to the formation of organized sarcomere. Advance in the role miR-1 plays in cardiac biological processes have put new perspectives on mechanisms of heart diseases.