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The Role of NFand#954;B in T-lymphocyte Development and Function | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Role of NFκB in T-lymphocyte Development and Function

Elisha de Valle1,2, Laurensius K. Lie1,2, Stuart P. Berzins3 and Raffi Gugasyan1,2,4*
1Centre for Immunology, Burnet Institute, Melbourne, Victoria, Australia
2Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia
3University of Ballarat, and Ballarat Cancer Research Centre, Victoria, Australia
4Department of Microbiology and Immunology, the University of Melbourne, Melbourne, Victoria, Australia
Corresponding Author : Raffi Gugasyan
Center for Immunolgy Burnet Institute
Melbourne, Victoria, Australia
Tel: 61-03-9282 2111
Fax: 61-03-9282 2100
E-mail: [email protected]
Received October 09, 2012; Accepted November 06, 2012; Published November 16, 2012
Citation: de Valle E, Lie LK, Berzins SP, Gugasyan R (2012) The Role of NFκB in T-lymphocyte Development and Function. J Clin Cell Immunol S12:009 doi:10.4172/2155-9899.S12-009
Copyright: © 2012 de Valle E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Initially identified as a nuclear factor in B cells, the family of NFκB transcription factors have since been found to operate in almost all cell types, regulating the transcription of a wide range of target genes. The NFκB signalling pathway is of particular importance to T lymphocytes, playing a prominent role in both T cell development and function. This review will focus on the current understanding of the roles of NFκB during thymic T cell development, with an emphasis on some of the emerging roles for NFκB signalling in regulating the development of non-conventional thymocyte lineages. We will also evaluate the function of NFκB signalling in the polarization of T-helper subsets in the periphery, and how NFκB intersects with other T cell-intrinsic pathways through mechanisms of signalling crosstalk. Dysregulated NFκB signalling is implicated in numerous disease states, and a thorough understanding of NFκB function during different phases of T cell development and function will be vital for optimal targeting in a therapeutic setting.

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