alexa The Role of Oxidative Stress in Carcinogenesis Induced By Metals in Breast Cancer Egyptian Females Sample at Dakahlia Governorate | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

The Role of Oxidative Stress in Carcinogenesis Induced By Metals in Breast Cancer Egyptian Females Sample at Dakahlia Governorate

Ahmed R. Ragab1*, Omar Farouk2, Mostafa M. Afify3, Afaf M. Attia1, Ayman El Samanoudy4,
Yasmeen M. Taalab1
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt
3Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
4Department of Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Corresponding Author : Ahmed R. Ragab
Department of Forensic Medicine and Clinical Toxicology
Faculty of Medicine, Mansoura University, Mansoura, Egypt
Tel: 050-344725
E-mail: [email protected]
Received November 13, 2013; Accepted January 25, 2013; Published January 27, 2014
Citation: Ragab AR, Farouk O, Afify MM, Attia AM, Samanoudy AE, et al. (2014) The Role of Oxidative Stress in Carcinogenesis Induced By Metals in Breast Cancer Egyptian Females Sample at Dakahlia Governorate. J Environ Anal Toxicol 4:207. doi: 10.4172/2161-0525.1000207
Copyright: © 2014 Ragab AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Trace metals and metals induced Oxidative stress have been implicated in breast carcinogenesis. Our study aimed to evaluate alteration of trace metals in breast tissue, oxidative stress and antioxidant status in breast cancer patients. This study included 120 female patients: 100 with breast cancer and 20 with benign breast diseases. Trace metals in breast tissue, lipid peroxidation and oxidative status were assessed. The present Results showed a significant increase in lead, cadmium, chromium, nickel and iron concentrations in malignant breast tissues compared to control group (P < 0.001). Also, a significant decline in Glutathione-S-transferase (GST), Glutathione Reductase (GR) and Total Antioxidant Capacity (TAC) levels; however a significant rise in Malondialdehyde (MDA) and Ferritin levels was detected in patients with breast cancer compared to controls. In conclusion, the alteration of the elemental content in cancerous breast tissues and the disruption of oxidant/antioxidant balance highlight the role of trace metals in cancer development.

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