alexa The Role of Palmitoylethanolamide, an Autacoid, in the
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

The Role of Palmitoylethanolamide, an Autacoid, in the Symptomatic Treatment of Muscle Cramps: Three Case Reports and Review of Literature

Jan Keppel Hesselink* and David J. Kopsky
Institute for Neuropathic Pain, The Netherlands
*Corresponding Author : Jan M Keppel Hesselink
Institute for Neuropathic Pain, Netherlands
Tel: 0031-6-51700527
E-mail: [email protected]
Received February 06, 2016; Accepted March 20, 2016; Published March 25, 2016
Citation: Hesselink JMK, Kopsky DJ (2016) The Role of Palmitoylethanolamide, an Autacoid, in the Symptomatic Treatment of Muscle Cramps: Three Case Reports and Review of Literature. J Clin Case Rep 6:744. doi:10.4172/2165-7920.1000744
Copyright: © 2016 Hesselink JMK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Physicians frequently see patients suffering from muscular cramps. Diagnosis of muscular cramps in general is not complex and can mostly be based on history and physical examination only. However, there is no clear evidence for the efficacy of pharmacological or other treatments for muscular cramps, apart from magnesium salts in pregnancy-associated cramps. New therapies are therefore urgently needed. We present three patients with treatment-refractory muscular cramps who responded favorably to treatment with the supplement and endogenous lipid messenger, the autacoid palmitoylethanolamide (PEA).


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