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The Role of Physical Activity in the Treatment and Prevention of Depression Mediated by Immune Modulatory Effects | OMICS International | Abstract
ISSN: 2157-7595

Journal of Yoga & Physical Therapy
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Review Article

The Role of Physical Activity in the Treatment and Prevention of Depression Mediated by Immune Modulatory Effects

Harris A Eyre1,2, Kristy Sanderson3 and Bernhard T Baune1*

1Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia

2School of Medicine and Dentistry, James Cook University, Townsville, Australia

3Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia

*Corresponding Author:
Bernhard T Baune
Discipline of Psychiatry
School of Medicine
University of Adelaide
Adelaide, SA 5005, Australia
Tel: +61 8 8222 5141
Fax: +61 8 8222 2865
E-mail: [email protected]

Received Date: May 12, 2014; Accepted Date: June 24, 2014; Published Date: July 07, 2014

Citation: Eyre HA, Sanderson K, Baune BT (2014) The Role of Physical Activity in the Treatment and Prevention of Depression Mediated by Immune Modulatory Effects. J Yoga Phys Ther 4:165. doi: 10.4172/2157-7595.1000165

Copyright: © 2014 Eyre HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Depression is a major public health concern and a global priority for research and development. The role of Physical Activity (PA) in the treatment and prevention of psychiatric disorders (e.g. depression, anxiety disorders, bipolar disorder and age-related cognitive dysfunction) has been developing in recent times with a significant number of quality trials emerging. This paper aims to provide an up-to-date, critical assessment of the epidemiological, clinical trial and a focus of clinical immunological evidence for PA interventions in the treatment and prevention of depression. A review of the literature suggests higher levels of PA and Cardio-Respiratory Fitness (CRF) are associated with lower levels of depressive symptoms, lower incidence of depression and lower levels of inflammation. Clinical trials suggest that aerobic, resistance and mind-body PA types may be therapeutic in the treatment of subsyndromal and major depression, as well as relapse prevention. Clinical neuroscience studies suggest, among other mechanisms, PA may be anti-inflammatory – with PA subtypes having varying anti-inflammatory effects – and this may be associated with clinical efficacy, as well as personalized treatment approaches. This paper proposes an integrated epidemiological, clinical and neuroscience research approach to this field in order to enhance the efficacy of preventive measures in the future.


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