alexa The Role of Pre- and Probiotics in the Treatment of Inflammatory Bowel Disease | OMICS International | Abstract
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
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Review Article

The Role of Pre- and Probiotics in the Treatment of Inflammatory Bowel Disease

John K. Triantafillidis*, Filippos Georgopoulos and Emmanuel Merikas

Department of Gastroenterology and Center for inflammatory Bowel Disease, “Saint Panteleimon” General Hospital, Nicea, Greece

*Corresponding Author:
Prof John K. Triantafillidis
Associated Professor
“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania. Head
Department of Gastroenterology and Center for Inflammatory Bowel Disease
“Saint Panteleimon” General Hospital, Nicea, Greece
Tel: (Greece)-6944432917
Fax: (Greece)-2105810970
E-mail: [email protected]

Received Date: October 13, 2011; Accepted Date: November 11, 2011; Published Date: November 21, 2011

Citation: Triantafillidis JK, Georgopoulos F, Merikas E (2011) The Role of Pre- and Probiotics in the Treatment of Inflammatory Bowel Disease. J Microbial Biochem Technol S1:005. doi: 10.4172/1948-5948.S1-005

Copyright: © 2011 Triantafillidis JK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and r

Abstract

Many patients with inflammatory bowel disease use alteranative therapy, mainly probiotics and synbiotics, to manage this intestinal condition. Despite widespread use of these natural therapies by patients, health care providers may be unfamiliar with probiotics as a treatment modality. This review describes the rationale for use of probiotics in patients with active or inactive inflammatory bowel disease, their mechanism(s) of action, and recent controlled clinical studies in which efficacy of probiotics, prebiotics and synbiotics in patients with active or inactive inflammatory bowel disease has been explored. Certain probiotics, particularly E. coli Nissle 1917 and a multi-agent mixture VSL#3, may be benefit patients with UC or pouchitis, while LactoBacillus rhamnosus GG appears less useful. In general, probiotics show potential for therapeutic application mainly in pouchitis and to a lesser degree in UC, while their effects in maintenance therapy for CD have been much less promising. While there is suggestion of benefit when patients with ulcerative colitis use bacterial therapies small sample sizes and methodological weeknesses in study designs necessitate that additional studies must be conducted before probiotics and or synbiotics can be routinely recommended in clinical practice.

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