alexa The Role of Prebiotics and Probiotics in Human Health
ISSN: 2329-8901

Journal of Probiotics & Health
Open Access

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Review Article

The Role of Prebiotics and Probiotics in Human Health

Corliss A O’Bryan, Dolar Pak, Philip G Crandall, Sun Ok Lee and Steven C Ricke*
Center for Food Safety, Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA
Corresponding Author : Steven C Ricke
Center for Food Safety, Department of Food Science
University of Arkansas, 2650 N Young Ave
Fayetteville, AR 72704, USA
Tel: (479) 575-4678
Fax: (479) 575-6936
E-mail: [email protected]
Received March 28, 2013; Accepted March 28, 2013; Published May 30, 2013
Citation: OBryan CA, Pak D, Crandall PG, Lee SO, Ricke SC (2013) The Role of Prebiotics and Probiotics in Human Health. J Prob Health 1:108. doi:10.4172/2329-8901.1000108
Copyright: © 2013 OBryan CA, et aL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


There has recently been a significant increase in research on the potential health benefi ts associated with probiotics and prebiotics. Some effects attributed to selected probiotics or prebiotics have been proved by clinical trials, while others have been acquired on the basis of in vitro tests which need to be replicated in vivo in order to be validated. Clinical reports in the literature for the application of probiotics have been done for the treatment of infectious diseases including viral, bacterial or antibiotic associated diarrhea, lowering of serum cholesterol, decreased risk of colon cancer, improved lactose digestion, and altered intestinal microbiota. However, information on probiotic species, a specifi c strain-therapeutic application, and adequate dosages, is not yet suffi cient to allow rational consumption. Moreover, prebiotic oligosaccharides are poorly understood in regard to their fermentation profi les and dosages required for health effects. The present review summarizes some of the literature in regard to clinical or therapeutic trials of probiotics and prebiotics.


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