alexa The Role of Quetiapinein the Treatment of Alzheimer's Disease
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
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Review Article

The Role of Quetiapinein the Treatment of Alzheimer's Disease

Pietro Gareri1, Luca Gallelli2*, Domenico Pirritano3, Pierandrea Rende2, Caterina Palleria2, Emilio Russo2, Alberto Castagna1, Amalia Cecilia Bruni1, Santo Gratteri4 and Giovambattista De Sarro2
1Centro Regionale di Neurogenetica, Lamezia Terme Hospital, ASP Catanzaro, Italy
2Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy
3Department of Neuroscience, “San Giovanni di Dio” Hospital, Crotone, Italy
4Chair of Forensic Medicine, Department of Experimental Medicine, School of Medicine, University of Catanzaro, Italy
Corresponding Author : Luca Gallelli
Department of Health Science
Operative Unit of Clinical
Pharmacology and Pharmacovigilance
University of Catanzaro, Italy
Tel: +39-0961-7123
E-mail: [email protected]
Received January 20, 2015; Accepted February 28, 2015; Published March 3, 2015
Citation: Gareri P, Gallelli L, Pirritano D, Rende P, Palleria C, et al. (2015) The Role of Quetiapine in the Treatment of Alzheimer's Disease. J Gerontol Geriatr Res 4:197 doi:10.4172/2167-7182.1000197
Copyright: © 2015 Gareri P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Behavioral and psychological symptoms in dementia (BPSD) include an array of neuropsychiatric symptoms, such as delusions, hallucinations, aggression, and agitation. In recent years, the use of antipsychotics, both conventional and atypical, has been widely debated because of concerns about their safety in treating behavioral disturbances in elderly patients affected with dementia, and the possible risks for stroke and sudden death. In this review we described the pharmacokinetic of quetiapine, its correlation in patients with Alzheimer’s disease and its possible role in BPSD. Quetiapine has a bioavailability of 5-13%, about 83% is bound to plasma protein and is largely metabolized in the liver through CYP3A4, the mean plasma half-life is about 6 hand clearance is reduced by 40% in the elderly. Usually CYP3A4 inhibitors are able to increase the plasma levels of quetiapine, while CP3A4 inducers accelerating the drug clearance reduce the quetiapine plasma levels. Quetiapine does not affect metabolism of other compounds known to be metabolized by CYP system. Studies showing its effectiveness for treating BPSD and the authors’clinical experience are reported too. In conclusion, quetiapine appears to be effective for treating BPSD

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