alexa The Role of Receptors for Advanced Glycation End Produc
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

The Role of Receptors for Advanced Glycation End Product in Pancreatic Carcinogenesis

Ali Hafez El-Far*
Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Egypt
Corresponding Author : Ali Hafez El-Far
Department of Biochemistry
Faculty of Veterinary Medicine
Damanhour Univ., Egypt
Tel: +20452167080
E-mail: [email protected]
Received: December 22, 2015 Accepted: January 11, 2016 Published: January 14, 2016
Citation: El-Far AH (2016) The Role of Receptors for Advanced Glycation End Product in Pancreatic Carcinogenesis. Pancreat Disord Ther 6:166. doi:10.4172/2165-7092.1000166
Copyright: © 2016 El-Far AH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Pancreatic cancer is the fourth-leading cause of cancer deaths worldwide that considered as the malignant tumor with the poorest prognosis and the lowest survival rate. This extremely violent disease is rarely diagnosed at an early level and difficult to treat due to its resistance to radiation therapy and chemotherapy. Here, we show that the receptor for advanced glycation end products (RAGE) and its ligands, advanced glycation end products (AGEs), high-mobility group box 1 (HMGB1) and S100 protein family are required for pancreatic cancer development, angiogenesis and metastasis through up-regulation of some anti-apoptotic molecules as matrix metalloproteinase -9 (MMP-9), kinase insert domain receptor (KDR), vascular endothelial growth factor (VEGF), platelet-derived growth factor-B (PDGF-B), hypoxia-inducible factor 1 (HIF1α), signal transducer and activator of transcription 3 (pSTAT3) and nuclear factor kappa B (NF-κB). In addition to the decrease in reactive oxygen species (ROS) those favouring the cancer cell growth and metastasis. The role of RAGE in pancreatic carcinogenesis needs further studies to investigate the relationship of RAGE with other anti-apoptotic and apoptotic molecules and examine the therapeutic potentials of anti-RAGE drugs for pancreatic cancer.

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