The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and RepairBrendan Jones1 and Gerard F. Hoyne1,2,3,4*
- *Corresponding Author:
- Gerard Hoyne
Professor, School of Health Sciences
University of Notre Dame Australia
Fremantle, Western Australia 6959, Australia
E-mail: [email protected]
Received date: October 26, 2016; Accepted date: December 23, 2016; Published date: January 03, 2017
Citation: Jones B, Hoyne GH (2017) The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair. J Clin Cell Immunol 8:482. doi: 10.4172/2155-9899.1000482
Copyright: © 2017 Jones B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory T cells. In this review we examine the process of exercise induced muscle damage to provide comparisons of how this may follow a similar coordinated response as that mediated by toxin induced damage.