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The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair

Brendan Jones1 and Gerard F. Hoyne1,2,3,4*

1School of Health Sciences, University of Notre Dame Australia, Fremantle, Western Australia 6959, Australia

2Institute of Health Research, University of Notre Dame Australia, Fremantle, Western Australia 6959, Australia

3Centre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology and Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands 6009, Australia

4Institute for Respiratory Health, Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Nedlands 6009, Australia

*Corresponding Author:
Gerard Hoyne
Professor, School of Health Sciences
University of Notre Dame Australia
Fremantle, Western Australia 6959, Australia
Tel: 61-8-94330236
Fax: 61-8-94330210
E-mail: [email protected]

Received date: October 26, 2016; Accepted date: December 23, 2016; Published date: January 03, 2017

Citation: Jones B, Hoyne GH (2017) The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair. J Clin Cell Immunol 8:482. doi: 10.4172/2155-9899.1000482

Copyright: © 2017 Jones B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory T cells. In this review we examine the process of exercise induced muscle damage to provide comparisons of how this may follow a similar coordinated response as that mediated by toxin induced damage.

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