The Role of Tissue Microenvironment in Breast Cancer Development and Importance of its Behavioral Profiling for Individually Tailored Therapy
Jessenius medical faculty, Department of Obstetrics and Gynecology, Comenius University in Martin, Slovak republic
- *Corresponding Author:
- Pavol Zubor, MD, PhD
Jessenius Medical Faculty
Comenius University in Martin
Department of Obstetrics and Gynecology
Kollarova 2, 036 01, Martin, Slovak republic
Tel: 00421 43 4203 242
Fax: 00421 43 413 41 85
E-mail: [email protected]
Received Date: December 20, 2011; Accepted Date: December 22, 2011; Published Date: December 22, 2011
Citation: Zubor P (2011) The Role of Tissue Microenvironment in Breast Cancer Development and Importance of its Behavioral Profiling for Individually Tailored Therapy. J Cancer Sci Ther S2:e001 . doi:10.4172/1948-5956.S2-e001
Copyright: © 2011 Zubor P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Invasive breast cancer is the endpoint of complicated evolutionary process starting in TDLU of mammary gland. It is the network of multiple-step mechanism including cell proliferation, differentiation, atypical intracellular expression and signaling leading to the misbalance between mammary epithelial cells and breast tissue microenvironment. The disruption of epithelial-stromal equilibrium can lead to the epithelial carcinogenesis, progressive stromal invasion and metastatic spread in the final stages. Although we know some of the histopathologic features in these mechanisms, the molecular profile of these events is still not adequately responded, and remains the scope for future research.