The Role of Transporters in the Pharmacokinetics of Antibiotics
|Hua WJ* and Hua WX|
|Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China|
|*Corresponding Author :||Hua WJ
Department of Pharmacy
The First Affiliated Hospital of Nanchang University, Nanchang, China
Tel: +86 791 6361194
Fax: +86 791 6361195
E-mail: [email protected]
|Received August 12, 2014; Accepted October 29, 2014; Published October 31, 2014|
|Citation: Hua WJ, Hua WX (2014) The Role of Transporters in the Pharmacokinetics of Antibiotics. Adv Pharmacoepidemiol Drug Saf 3:168. doi:10.4172/2167-1052.1000168|
|Copyright: © 2014 Hua WJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aims: Various transporters including efflux transporters and uptake transporters play an important role in the pharmacokinetics of drugs. At present, interestingly, more and more studies had found that numbers of antibiotics were the substrates of transporters, and these antibiotics were usually combined with other drugs to treat disease more effectively in clinic. Therefore, it is necessary to focus on the role of transporters in pharmacokinetics and drugdrug interactions of antibiotics.
Methods: This review summarized the findings of recent studies as well as information obtained from several databases (update to June 2012): ISI Web of Knowledge SM (ISI WoK), SciFinder (Caplus, Medline, Registry,Casreact, Chrmlist, Chemcasts) and PubMed (indexed for Medline).
Results: The present review will provides useful information for studying the role of transporters in pharmacokinetics and drug-drug interactions of antibiotics, and should be of help to those intending to further research on these topics.
Conclusions: The drug transporter plays a significant role in the pharmacokinetics and drug-drug interactions of antibiotics.