alexa The Roles of Adipose Tissue and Inflammation in Gestati
ISSN: 2165-8048

Internal Medicine: Open Access
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Review Article

The Roles of Adipose Tissue and Inflammation in Gestational Diabetes Mellitus

Tiffany A Moore Simas1-3* and Silvia Corvera4
1Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA
3Department of Obstetrics and Gynecology, UMass Memorial Health Care, Worcester, MA, USA
4Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
*Corresponding Author : Tiffany A. Moore Simas, MD
MPH, Med, University of Massachusetts Medical School
UMass Memorial Health Care - Memorial Campus
Department of Obstetrics & Gynecology
119 Belmont Street - Jaquith 2.008, Worcester
Massachusetts 01605, USA
Tel: 1-508-334-6678; Pager: 1-508-426-0095
Fax: 1-508-334-9277
Received August 18, 2014; Accepted October 26, 2014; Published October 31, 2014
Citation: Simas TAM, Corvera S (2014) The Roles of Adipose Tissue and Inflammation in Gestational Diabetes Mellitus. Intern Med S6:010. doi:10.4172/2165-8048.S6-010
Copyright: © 2014 Simas TAM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance with first onset or first identification in pregnancy. It is one of the most common complications of pregnancy with a prevalence ranging from 3% to upwards of 16% depending on the screened population and whether a 1 or 2-step screening algorithm is utilized. Its occurrence has historically been predominantly attributed to pro-diabetogenic placental hormone secretion. However, there is emerging evidence to indicate that its mechanistic underpinnings are more complex; similar to type 2 Diabetes Mellitus (T2DM), adipose tissue dysfunction and associated inflammation may be key etiologic factors for the development of GDM. In support of this view, women with a history of GDM are at high risk of subsequent T2DM development and their offspring at increased risk of obesity and metabolic syndrome across their life span. With immediate and long term consequences of GDM on mother and offspring, etiologic understanding that can inform therapeutic and preventative targets is essential. This review article explores the existing literature as it relates to associations of GDM with expansion of adipose tissue depots, secretion of adipose derived biologically active factors, and inflammation and inflammatory related substances.


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