alexa The Safe and Effective Plateletpheresis | OMICS International | Abstract
ISSN: 2167-1168

Journal of Nursing & Care
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Research Article

The Safe and Effective Plateletpheresis

Bibekov Z*, Burkitbaev S, Skorikova A, Kenzhin R and Magzumova

Research and Production Center of Transfusion, Astana, Kazakhstan

*Corresponding Author:
Zharas Bibekov
Research and Production
Center of Transfusion, Astana
Kazakhstan
Tel: +77013509113
E-mail: [email protected]

Received date: March 06, 2017; Accepted date: May 23, 2017; Published date: May 31, 2017

Citation: Bibekov Z, Burkitbaev S, Skorikova A, Kenzhin R, Magzumova (2017) The Safe and Effective Plateletpheresis. J Nurs Care 6:402. doi:10.4172/2167-1168.1000402

Copyright: © 2017 Bibekov Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


Abstract

At the Research and Production Center of Transfusion platelet production have mainly supported (about 99%) by apheresis. However, apheresis donations have limitations caused by donor fitness due to both their preferences and their platelet pre-count validity. So, it is important to maintain of single donor high-dose plateletpheresis by improving its efficacy and safety. The aim of study was to develop of safe-effective approaches of plateletpheresis. Donors had been attracted to the study if they had filed of informed consent for post-collection blood sampling in advance. They were selected with following criteria: male, age 18-60 years, weight ≥ 55 kg, Hb ≥ 125.0 g/L, PLTs ≥ 160.0 × 109/L. Target number of platelets need to be obtained was chosen under calculation of estimated donor post-collection platelets. Platelets were harvested by «Hemonetics MCS plus» separators with LDP protocol, blood samples were counted by «Sysmex» hematology analyzer. Thus, 16 apheresis procedures with volunteer-donors were studied. The following results are demonstrated in the present study: donor pre-collection platelets 286.0 × 109/L ± 27.2; donor blood volume calculated by separator 5481.6 mL ± 408.5; platelet yield 473.1 × 109/unit ± 47.7; donor blood processed 3190.8 mL ± 189.7; donor platelets processed 763.0 × 109 ± 55.6; actual donor post-collection platelets measured by lab 193.3 × 109/L ± 18.6; platelet collection efficacy 61.9% ± 3.0. The values of estimated postcollection platelets 199.0 × 109/L ± 21.3 were not significantly different from those with actual post-collection platelets 193.3 × 109/L ± 18.6 (χ2=0.401). Thus, plateletpheresis efficacy has to be controlled using calculation of estimated donor post-collection platelets by making sure that safe threshold of post-apheresis platelet number is provided. The further studies have to be proceeding due to small number of observations.

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