alexa The Significance of Electrocardiographic Abnormalities and Serology for T. cruzi Infection | OMICS International | Abstract
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Research Article

The Significance of Electrocardiographic Abnormalities and Serology for T. cruzi Infection

Monique Lirio1, Zuinara Pereira Gusmão Maia1, Maria Nakatani1, Sanjay R. Mehta2 and Roberto Badaro1*

1Federal University of Bahia Hospital Complex, Bahia, Brazil

2Division of Infectious Diseases, University of California San Diego, California, USA

*Corresponding Author:
Roberto Badaro
Federal University of Bahia Hospital Complex
Bahia, Brazil
Tel: (5571)3235-4901/3283-6207
Fax: (5571)3247-2756
E-mail: [email protected] or [email protected]

Received Date: October 09, 2013; Accepted Date: October 28, 2013; Published Date: October 30, 2013

Citation: Lirio M, Maia ZPG, Nakatani M, Mehta SR, Badaro R, et al. (2013) The Significance of Electrocardiographic Abnormalities and Serology for T.cruzi Infection. J Trop Dis 1:121. doi: 10.4172/2329-891X.1000121

Copyright: © 2013 Lirio M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Electrocardiography (EKG) is a basic complementary exam in the evaluation patients with Chagas disease (CD), where findings can precede symptoms and physical examination abnormalities.

Objective: To correlate positive Chagas serology and electrocardiographic abnormalities associated with chronic chagasic cardiomyopathy.

Method: We evaluated the correlation between results of an ELISA using crude antigen (TcLys) and recombinant antigen (TcF) with the presence of EKG disturbances, within a cohort of individuals with either epidemiologic risk or clinical symptoms suggestive of CD, sent to our Laboratory for Tropical Diseases for testing in state of Bahia, Brazil.

Results: 84 individuals had a positive ELISA using TcLys or TcF antigen. Overall, 49 patients (58.3%) were symptomatic with CD, 42 (85.7%) with isolated evidence of the cardiac form, one (2.0%) with megacolon and mixed (megaviscera and cardiac) in six (12.2%). TcLys ELISA was positive in 45/49 (91.8%) and TcF in 42/49 (85.7%) of the symptomatic patients. The most common EKG abnormality, Complete Right Bundle Branch Block (CRBBB), was seen in 47/84 patients (56.0%) of the patients. Interestingly, in 11/47 (23.4%) of the patients with CRBBB, serologies were discordant. Conclusions: EKG plays a key role in the initial evaluation of patients with positive Chagas serology using crude or recombinant antigens. Individuals with positive serology should be carefully followed with periodical cardiac medical examination to early detect EKG abnormality compatible with CD.


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