The Sirtuin System: The Holy Grail of Resveratrol?
|Dilbahar S. Mohar* and Shaista M|
|Division of Cardiology, University of California, Irvine, California, USA|
|Corresponding Author :||Dilbahar S. Mohar, MD
University of California
Irvine School of Medicine
Division of Medicine
11326 Adobe Circle, Irvine, California 92617, USA
E-mail: [email protected]
|Received May 23, 2012; Accepted October 05, 2012; Published October 08, 2012|
|Citation: Mohar DS, Malik S (2012) The Sirtuin System: The Holy Grail of Resveratrol? J Clin Exp Cardiolog 3:216. doi:10.4172/2155-9880.1000216|
|Copyright: © 2012 Mohar DS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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The oxidative stress theory has been associated with atherosclerosis and has prompted a multitude of studies to evaluate the effects of antioxidants on cardiovascular disease prevention. Resveratrol, a relatively new antioxidant has gained considerable curiosity. This polyphenol stilbene identified in grape skin, is believed to be the main component contributing to the anti-atherosclerotic benefits linked to red wine consumption. It has demonstrated the ability to protect endothelial cells from lipid damage, promote vasodilation via modulation of nitric oxide synthesis, and inhibit platelet aggregation and smooth muscle proliferation. Although the complete mechanism of Resveratrol has yet to be fully elucidated, the Sirtuin system, consisting of 7 highly conserved families of regulator genes, are thought to be instrumental in establishing the various health benefits. In this article we assess the current applications, mechanism, pharmacokinetics, bioavailability, and safety profile of the novel antioxidant Resveratrol and provide an in-depth review of the influence of the Sirtuin system on the Resveratrol mechanism of action. We resolve that while early data on Resveratrol are promising, the antioxidative and ultimately, anti-atherosclerotic potential depends on further clarification of the intricate and complex relationship between Resveratrol and the Sirtruin system.