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The Structure of the Electric Double Layer of Macromolecules | 45591

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Abstract

The Structure of the Electric Double Layer of Macromolecules Suspended in Human Cerebrospinal Fluid

Leszek Herbowski and Henryk Gurgul

The cerebrospinal fluid is a dilute suspension of large colloidal macroparticles such as protein molecules and cells. Based on microscopic observations of cerebrospinal fluid samples and some theoretical data the authors could develop a schematic structure of electric double layer around the biomolecules suspended in cerebrospinal fluid. Numerical results show that the averaged diameter of the observed macroparticles is 5,1 μm. We could observe Brownian motions of large biomolecules as a result of thermal nanoparticles movements. Understanding ions composition of cerebrospinal fluid we could state that the compact Stern layer consists of sodium cations and the Gouy layer of chloride anions. Our calculations reveal that the thickness of the Stern layer surrounding macroparticles in cerebrospinal fluid is 0,366 nm.

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