alexa The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Mini Review

The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines

Ming-Xia Song1, Chang-Ji Zheng2, Xian-Qing Deng1, Zhi-Yu Wei2 and Hu-Ri Piao2*

1 JingGangshan University College of Medicine, Ji’an 343100, P R China

2 Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education; Yanbian University College of Pharmacy, Yanji 133002, P R China

*Corresponding Author:
Hu-Ri Piao
Yanbian University College of Pharmacy
Yanji, Jilin 133002, P R China
Tel: + 86-433-2435003
Fax: + 86-433-2435026
E-mail: [email protected]

Received date: April 21, 2014; Accepted date: May 21, 2014; Published date: May 23, 2014

Citation: Song MX, Zheng CJ, Deng XQ, Wei ZY, Piao HR (2014) The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines. Med chem 4:441-448. doi: 10.4172/2161-0444.1000177

Copyright: © 2014 Song MX, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A large number of reports have been published in recent years regarding the use of N-carboxymethyl rhodanines as antimicrobial agents. Molecules belonging to this structural class have been reported to exhibit good inhibitory activities towards various Gram-positive bacteria, including several multidrug-resistant strains such as methicillinresistant Staphylococcus aureus and quinolone-resistant Staphylococcus aureus. In this mini-review, we have provided a summary of recent research directed towards the synthesis of N-carboxymethyl rhodanines, and their pharmacological evaluation as antimicrobial agents.

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