The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines
- *Corresponding Author:
- Hu-Ri Piao
Yanbian University College of Pharmacy
Yanji, Jilin 133002, P R China
Tel: + 86-433-2435003
Fax: + 86-433-2435026
E-mail: [email protected]
Received date: April 21, 2014; Accepted date: May 21, 2014; Published date: May 23, 2014
Citation: Song MX, Zheng CJ, Deng XQ, Wei ZY, Piao HR (2014) The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines. Med chem 4:441-448. doi: 10.4172/2161-0444.1000177
Copyright: © 2014 Song MX, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A large number of reports have been published in recent years regarding the use of N-carboxymethyl rhodanines as antimicrobial agents. Molecules belonging to this structural class have been reported to exhibit good inhibitory activities towards various Gram-positive bacteria, including several multidrug-resistant strains such as methicillinresistant Staphylococcus aureus and quinolone-resistant Staphylococcus aureus. In this mini-review, we have provided a summary of recent research directed towards the synthesis of N-carboxymethyl rhodanines, and their pharmacological evaluation as antimicrobial agents.