The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen
- Corresponding Author:
- Ormerod LP
Preston New Rd, Blackburn
Received Date: March 11, 2014; Accepted Date: April 23, 2014; Published Date: April 26, 2014
Citation: Haines SA, Mittal R and Ormerod LP (2014) The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen. J Mycobac Dis 4:151. doi:10.4172/2161-1068.1000151
Copyright: © 2014 Haines SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Chest Clinic in Blackburn UK, a high Tuberculosis (TB) incidence area of the United Kingdom.
Methods: Retrospective analysis of a prospectively compiled database of TB notifications. The clinical characteristics and management of those cases with isonazid resistance (with or without additional streptomycin resistance) for the years 1989-2008 inclusive is described.
Results: 36 patients with proven and 3 with presumed isoniazid resistance were treated, 15 with pulmonary and 21 with non-pulmonary confirmed cultures. 35 patients (92%) were treated with a regimen of nine months rifampicin and ethambutol, supplemented by two months initial pyrazinamide (2RZE/7RE). No clinical or bacteriological relapses occurred.
Conclusion: This retrospective cohort study with a minimum of 12 months post treatment follow-up of all cases shows that a nine-month regimen, 2RZE/7RE with careful monitoring can be associated with satisfactory results in the treatment of isoniazid-resistant TB.