alexa The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen
ISSN: 2161-1068

Mycobacterial Diseases
Open Access

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Research Article

The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen

Sarah A Haines1, Rahul Mittal1 and Lawrence Peter Ormerod1-3*

1Chest Clinic, Royal Blackburn Hospital, Blackburn Lancaster, UK

2Lancashire Postgraduate School of Medicine, University of Central Lancashire, Preston, UK

3University of Manchester, Oxford Rd, Manchester M13 9PL, UK

Corresponding Author:
Ormerod LP
Beardwood Hospital
Preston New Rd, Blackburn
Lancashire, UK
Tel: 01706229594

Received Date: March 11, 2014; Accepted Date: April 23, 2014; Published Date: April 26, 2014

Citation: Haines SA, Mittal R and Ormerod LP (2014) The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen. J Mycobac Dis 4:151. doi:10.4172/2161-1068.1000151

Copyright: © 2014 Haines SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Chest Clinic in Blackburn UK, a high Tuberculosis (TB) incidence area of the United Kingdom.

Methods: Retrospective analysis of a prospectively compiled database of TB notifications. The clinical characteristics and management of those cases with isonazid resistance (with or without additional streptomycin resistance) for the years 1989-2008 inclusive is described.

Results: 36 patients with proven and 3 with presumed isoniazid resistance were treated, 15 with pulmonary and 21 with non-pulmonary confirmed cultures. 35 patients (92%) were treated with a regimen of nine months rifampicin and ethambutol, supplemented by two months initial pyrazinamide (2RZE/7RE). No clinical or bacteriological relapses occurred.

Conclusion: This retrospective cohort study with a minimum of 12 months post treatment follow-up of all cases shows that a nine-month regimen, 2RZE/7RE with careful monitoring can be associated with satisfactory results in the treatment of isoniazid-resistant TB.


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