The Tumor Suppressive Role of PATZ1 in Thyroid Cancer: A Matter of Epithelial-Mesenchymal TransitionMonica Fedele1*, Laura Cerchia1and Gennaro Chiappetta2
- *Corresponding Author:
- Monica Fedele
Institute of Experimental Endocrinology and Oncology (IEOS)
National Research Council (CNR)
via S. Pansini 5, 8031 Naples, Italy
E-mail: [email protected]
Received date: February 09, 2016 Accepted date: March 31, 2016 Published date: April 07, 2016
Citation: Fedele M, Cerchia L, Chiappetta G (2016) The Tumor Suppressive Role of PATZ1 in Thyroid Cancer: A Matter of Epithelial-Mesenchymal Transition. Chemo Open Access 5:198. doi: 10.4172/2167-7700.1000198
Copyright: © 2016 Fedele M, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PATZ1 is a chromatin-regulating factor with emerging roles in stemness and cancer. It has been suggested to play a dual oncogene/tumor suppressor role depending on the cellular context, but its function in human tumor biology is still far to be completely elucidated. We have recently identified its tumor suppressive role in thyroid carcinogenesis, possibly through the association between PATZ1 and p53 to oppose epithelial-mesenchymal transition and cell migration. These are major processes in tumor progression, local invasion, metastasis, and therapeutic resistance and play a recognized role in the development of thyroid cancer, particularly anaplastic thyroid carcinoma, but many questions about how they are orchestrated remain opened. Elucidation of the mechanisms regulating epithelial-mesenchymal transition and cell migration can suggest new candidates for antimetastatic drug development that could lead to more effective therapies for highly aggressive and lethal thyroid cancers.