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ISSN: 2161-0444

Medicinal Chemistry
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Review Article

The Tyrosine Phosphatase SHP2: A Key Molecule Linked both Type 2 Diabetes and Cancers?

Hu Luo, Chunlan Tang, Xuemei Yang and Xiangdong Zhou*

Department of Respiratory Medicine, the First Affiliated Hospital of Third Military Medical University, Chongqing 400038, P.R. China

*Corresponding Author:
Zhou Xiangdong
Department of Respiratory Medicine
The First Affiliated Hospital of Third Military Medical University
No.30 in Gao Tanyan Street
Sha Pingba Distinct, Chongqing, P.R. China
Tel: +86-023-687-556-79
E-mail: [email protected]

Received date: February 12, 2014; Accepted date: April 17, 2014; Published date: April 20, 2014

Citation: Luo H, Tang C, Yang X, Zhou X (2014) The Tyrosine Phosphatase SHP2: A Key Molecule Linked both Type 2 Diabetes and Cancers? Med chem 4:435-438. doi: 10.4172/2161-0444.1000175

Copyright: © 2014 Luo H, et al. This is an open-access article distributed under he terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Emerging epidemiological evidence suggests that T2DM may be associated with an increased risk of certain cancers. However, the underlying molecular mechanism linked these two diseases remains largely unknown. SHP2, a non-receptor protein tyrosine phosphatase encoded by pro-oncogene PTPN11, has been reported involved in insulin resistance through PI3K/Akt/mOTR signaling and has also been considered to play a vital role in carcinogenesis via Ras/Erk pathways. Based on our previous studies, we hypothesize that SHP2 may present a key molecule linked both T2DM and cancers through both Ras/Erk and PI3K/AKT/mTOR signaling pathways. We believe that the comprehensive and detailed investigation of SHP2 may provide a new insight into the underlying molecular mechanism linked both T2DM and cancers, thereby facilitating the process to discover novel therapeutic targets to prevent and treat cancers.

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