alexa The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex | OMICS International
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex

Najma Sultana1, Saeed Arayne M2 and Saeeda Nadir Ali2*

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

2Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

*Corresponding Author:
Saeeda Nadir Ali
Department of Chemistry
University of Karachi
Karachi-75270, Pakistan
E-mail: [email protected]

Received date: June 13, 2013; Accepted date: July 25, 2013; Published date: July 27, 2013

Citation: Sultana N, Saeed Arayne M, Ali SN (2013) The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex. Med chem 3:241-246. doi:10.4172/2161-0444.1000146

Copyright: © 2013 Sultana N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the present study, simple and fast spectrophotometricmethod have been reported for the determination of three macrolides i.e., erythromycin, roxithromycin and clarithromycin through charge transfer complexes. The method involves the interaction of macrolides with chloranilic acid in acetonitrile medium. Stoichiometry was found to be 1:1 for all the complexes. Under the optimizedconditions, the complexes were found to be absorbed at 498, 496 and 491 nm with in the linearity range of 3-36, 4-40 and 8-40 μg mL -1 with minimum detection limit 190, 600 and 370 ng mL -1 for respectively. The corresponding molar absorptivity values were determined to be 2.07×10 4 , 1.81×10 4 and 1.67×10 4 Mol -1 cm -1 respectively. The data is discussed in terms of oscillator’s strength, dipole moment, ionization potential, energy of complexes, resonance energy, association constant and Gibb’s free energy changes. Benesi- Hildebrand plots for all complexes have been constructed. Furthermore, the methods were successfully applied for the determination of studied macrolides in pharmaceutical formulations. The interday and intraday precision and percent recovery values were evaluated. Results of analysis were validated successfully. Commonly present excipients did not show interference during analysis

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