alexa The Use of Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis: An Overview of Open Labels and Ongoing Studies
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Review Article

The Use of Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis: An Overview of Open Labels and Ongoing Studies

Shahbeigi Saeed1*, Sepehry Amir Ali1,2 and Oger Joel1,3

1Neuroimmunology fellow from UBC Division of Neurology, Department of Medicine, Vancouver, Canada

2University of British Columbia (UBC), College for Interdisciplinary Studies, Graduate 3program in Neuroscience, Vancouver, Canada

3UBC Division of Neurology, Department of Medicine, Vancouver, Canada

Corresponding Author:
Dr Saeed Shahbeigi
UBC Hospital, 2211 Wesbrook Mall Room S-159
Vancouver BC Canada V6T 2B5, Canada
Tel: 604-971-3002
Fax: 604-822-0758
E-mail: [email protected]

Received date: May 08, 2014; Accepted dat: August 26, 2014; Published date: September 01, 2014

Citation: Saeed S, Amir Ali S, Oger Joe (2014) The Use of Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis: An Overview of Open Labels and Ongoing Studies. J Neurol Neurophysiol 5:219 doi:10.4172/2155-9562-5-1000219

Copyright: © 2014 Saeed S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Multiple sclerosis (MS) is a demyelinating disease of unknown etiology that affects the Central Nervous System
(CNS) where autoimmune-mediated mechanisms are thought to be at work. There are two possible options for
treating MS, to prevent damage, and to repair the already impaired CNS. Stem Cells (SC) therapy emerges as a
potential new hope for MS patients as it could accomplish both functions. There is a growing body of literature that
supports the potential of the SC for immunomodulation and re-myelination. Here we focus on examining the
registered published and on-going clinical trials using the Mesenchymal Stem Cell (MSC) therapy in MS. We have
found that a total of 85 patients were enrolled in 9 cell-base studies with encouraging results. These studies were
not statistically analyzed; however, they showed safety of the MSC therapy. Based on the results emerging from
these patients, who failed to respond to even immunosuppressive drugs, clinical improvement was observed in 62%,
a stable course in 22%; and 16% remaining in a progressive course. Given the evidence, we support that cell-based
therapies are safe and reasonable to initiate a double blind, randomized controlled trials. This would represent a
new and unique therapeutic approach for the progressive forms of MS.


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