alexa The Use of Whole-Body MR Imaging in Children with HMO, an Extended Case Study in Two Patients
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

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Case Report

The Use of Whole-Body MR Imaging in Children with HMO, an Extended Case Study in Two Patients

Heleen M Staal1*, Marjolein HG Dremmen2, Simon GF Robben2, Adhiambo MA Witlox1and Lodewijk W van Rhijn1

1Department of Orthopaedic Surgery, Maastricht University Medical Centre, Netherlands

2Department of Radiology, Maastricht University Medical Centre, Netherlands

*Corresponding Author:
Heleen Staal
Orthopedic Surgeon, Department of Orthopedic Surgery
Research School CAPHRI, Maastricht University Medical Centre
P Debyelaan 25, Maastricht, 6202 AZ, P.O. Box 5800, Netherlands
Tel: 31 6 26 88 27 61
E-mail: [email protected]

Received Date: December 22, 2015 Accepted Date: January 21, 2016 Published Date: January 25, 2016

Citation:Staal HM, Dremmen MH, Robben SG, Witlox AM, Rhijn LW (2016) The Use of Whole-Body MR Imaging in Children with HMO, an Extended Case Study in Two Patients. Pediatr Ther 6:275. doi:10.4172/2161-0665.1000275

Copyright: © 2016 Staal HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Background: Patients with hereditary multiple osteochondromas (HMO) undergo frequent radiographs to evaluate the growth of their osteochondromas. The conventional radiographic images clearly show the growth of the bony part of the osteochondromas and the growth direction of the long bones. The radiographs do not show the cartilage cap on top of the osteochondroma nor do they show the surrounding soft tissue or the cartilage of the nearby epiphysis. Alongside these disadvantages taking frequent radiographs carries the potential risk of inducing malignant degeneration through ionizing radiation. In this study we investigated the use of whole-body MR imaging as a screening tool to follow patients with HMO.

Findings: Two HMO affected children underwent two whole-body MR imaging scans in one-year time to identify the osteochondromas and to evaluate their growth. The MR images were compared to regular follow-up radiographs of these patients. All radiographically detectable osteochondromas were visible on the whole-body MR images. At least one osteochondroma was clearly seen on the whole-body MR images before detection was possible on the radiographs. The proton density sequence with fat suppression proved to be the best sequence to visualize osteochondromas.

Conclusion: Whole-body MR imaging is an effective follow-up tool for patients with hereditary multiple osteochondromas.


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