alexa The Utility of Diffusion-Weighted Magnetic Resonance Imaging for Discriminating and Early Detecting of Nasopharyngeal Carcinoma | OMICS International | Abstract
ISSN: 2155-9937

Journal of Molecular Imaging & Dynamics
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Review Article

The Utility of Diffusion-Weighted Magnetic Resonance Imaging for Discriminating and Early Detecting of Nasopharyngeal Carcinoma

Dechun Zheng, Yunbin Chen*, Yuqi Yao, Zhongshi Du and Xiaohong Deng

Department of Radiology, Fujian Medical University Teaching Hospital, Fujian Provincial Tumor Hospital & Institute, Fuzhou, Fujian, China

*Corresponding Author:
Yunbin Chen
Department of Radiology
Fujian Medical University Teaching Hospital
Fujian Provincial Tumor Hospital & Institute
Fuzhou, Fujian, China
E-mail: [email protected]

Received date: November 28, 2011; Accepted date: April 21, 2012; Published date: April 26, 2012

Citation: Zheng D, Chen Y, Yao Y, Du Z, Deng X (2012) The Utility of Diffusion- Weighted Magnetic Resonance Imaging for Discriminating and Early Detecting of Nasopharyngeal Carcinoma. J Mol Imaging Dynam 2:109. doi:10.4172/2155-9937.1000109

Copyright: © 2012 Zheng D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Purpose: To study the utility of Diffusion-Weighted Magnetic Resonance Imaging to distinguish among Nasopharyngeal Carcinoma (NPC), lymphoma, tuberculosis and nasopharyngitis which originates in nasopharynx.

Materials and Methods: Our hospital’s institutional review board approved this retrospective study. Forty-two patients with early stage NPC, sixteen with lymphoma, eleven with tuberculosis, and twenty-six with nasopharyngitis were included in this retrospectively study. All patients underwent both nasopharynx and skull base region MR Imaging and nasopharyngo-fiberscope biopsy in our hospital, and were finally diagnosed with histopathologically proven (n = 86) and clinical follow-up (n = 9). The Apparent diffusion coefficient (ADC) values were investigated by experienced radiologist, and averaged ADC value of per patient was compared in groups. Mean ADC values between two groups were compared by independent - samples T-test, and one-way Analysis of Variance was used to analyze mean ADC values among four groups.

Results: Mean ADC values of malignant nasopharyngeal lesions (early stage NPC and lymphoma) and benign nasopharyngeal lesions (tuberculosis and nasopharyngitis) were (0.708 ± 0.158) and (0.913 ± 0.168) × 10-3 mm2/s respectively (t = 6.05, P < 0.01). Mean ADC values of nasopharyngeal lesions of early stage NPC, lymphoma, tuberculosis and nasopharyngitis were (0.753 ± 0.135), (0.590 ± 0.156), (0.855 ± 0.137), and (0.935 ± 0.179) × 10-3 mm2/s respectively (F = 18.89, P < 0.01), and post multiple comparisons showed that they were all Statistical significance on 0.05 level between NPC, lymphoma, tuberculosis and nasopharyngitis except subgroup tuberculosis and nasopharyngitis (p = 0.55); An ADC value lower than or equal to 0.828 × 10-3 mm2/s was used as threshold for nasopharyngeal malignancy, with a sensitivity 82.8% and specificity of 70.3%. When the same ADC value ≤ 0.828 × 10-3 mm2/s was used as threshold to differentiate early stage NPC from nasopharyngitis, sensitivity and specificity were 78.6% and 69.2% respectively. When an ADC value ≤ 0.681 × 10-3 mm2/s was used as threshold to differentiate lymphoma from early stage NPC, sensitivity and specificity were 81.3% and 71.4% respectively.

Conclusion: MR DWI has a potential value in differentiating nasopharyngeal diseases.


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