The Validity of Reliability Measure in Threshold Perimetry
|Xiaolei Shao1,2*, Cecilia Fenerty3 and David B Henson2,3|
|1Department of Ophthalmology, the 2nd Xiangya hospital of Central South University, Changsha, China|
|2School of Biomedicine, University of Manchester, United Kingdom|
|3Manchester Royal Eye Hospital, Manchester, United Kingdom|
|Corresponding Author :||Xiaolei Shao
Department of Ophthalmology
The 2nd Xiang Ya hospital of Central South University
No.139 Middle People Road, Changsha 410011, P.R. China
E-mail: [email protected]
|Received November 08, 2010; Accepted January 19, 2011; Published January 24, 2011|
|Citation: Shao X, Fenerty C, Henson DB (2011) The Validity of Reliability Measure in Threshold Perimetry. J Clinic Experiment Ophthalmol 2:117. doi: 10.4172/2155-9570.1000117|
|Copyright: © 2011 Shao X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: To evaluate the color Doppler imaging (CDI) and pattern visual evoked potential (P-VEP) examinations in primary open angle glaucoma (POAG) patients and investigate the relation between flow velocities measured by CDI and P-VEP examination in POAG patients.
Methods: Sixty five POAG patients and 45 control subjects underwent CDI evaluation of the ophthalmic artery (OA), short posterior ciliary artery (SPCA) and central retinal arteries (CRA). The peak systolic velocities (PSV) and end-diastolic velocities (EDV) and resistive index (RI) of all retrobulbar vessels were measured. The latency and amplitude of P100 in P-VEP were recorded. The differences of CDI and P-VEP parameters among POAG and control groups were compared. The correlations between CDI parameters, visual field indices and P-VEP in POAG patients were evaluated by Pearson's correlation analysis.
Results: POAG patients had the lower EDV and higher RI in the OA, CRA and SPCA comparing with that of control subjects. Also, POAG patients had lower PSV in OA and CRA comparing with that of control subjects. The latency of P100 in VEP delayed and the amplitude of P100 decreased in the POAG patients comparing with that of the control group. The RI of OA and SPCA were negatively correlated with the mean deviation (MD) values in the POAG patients. The RI of OA was positively correlated with the PSD value in POAG patients. The MD values in POAG patients were negatively correlated with the latency time of P100. The RI of OA was positively correlated with the latency time of P100 and negatively correlated with the amplitude of P100 in the POAG patients.
Conclusions: The combination of the CDI and pattern VEP techniques provides further interpretation of ocular circulatory changes in POAG patients. Further studies are needed for assessment the relationship between circulatory and neural changes.