alexa The Viscous and External Forces Effect on the Thermal Denaturation of Peyrard-Bishop Model | OMICS International| Abstract

ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics

  • Research Article   
  • J Phys Chem Biophys 2015, Vol 5(5): 186
  • DOI: 10.4172/2161-0398.1000186

The Viscous and External Forces Effect on the Thermal Denaturation of Peyrard-Bishop Model

Hidayat W1,4*, Sulaiman A2,4, Viridi S3,4 and Zen FP1,4
1Theoretical High Energy Physics and Instrumentations Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, Indonesia
2Geostech Laboratory, Badan Pengkajian dan Penerapan Teknologi, Jakarta, Indonesia
3Nuclear Physics and Biophysics Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, Indonesia
4Indonesia Center for Theoretical and Mathematical Physics (ICTMP), Bandung, Indonesia
*Corresponding Author : Hidayat W, Theoretical High Energy Physics and Instrumentations Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung 40132, Indonesia, Tel: 62222500834, Email: [email protected]

Received Date: Jun 30, 2015 / Accepted Date: Oct 13, 2015 / Published Date: Oct 19, 2015

Abstract

The viscous and the external forces effect on thermal DNA denaturation of Peyrard-Bishop model are investigated. The calculation of the partition function to determine the stretching of hydrogen bonds has been performed by path integral Monte-Carlo. The result shows that the interaction between the viscous potential and external forces prevent DNA to unzip perfectly but allows DNA to split at a certain distance from its original position. The increase of the viscosity coefficient will reduce the melting temperature. The result obtained also showed how at certain temperature external potential give dominant contribution in denaturation, higher even than the viscosity effect.

Keywords: Denaturation; Path integral; Peyrard-Bishop; Viscosity

Citation: Hidayat W, Sulaiman A, Viridi S, Zen FP (2015) The Viscous and External Forces Effect on the Thermal Denaturation of Peyrard-Bishop Model. J Phys Chem Biophys 5: 186. Doi: 10.4172/2161-0398.1000186

Copyright: © 2015 Hidayat W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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