alexa Therapeutic and Antioxidant Potential in the Shell Extract of Prunus amygdalus against Dermal Mycosis
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Therapeutic and Antioxidant Potential in the Shell Extract of Prunus amygdalus against Dermal Mycosis

Nasreen Thebo1*, Wazir Sheikh1, M. Iqbal Bhangar2, Pervaiz Iqbal3 and M. Hassan Nizamani4
1Mycology Research laboratory Institute of Botany, University of Sindh, Jamshoro, Sindh, Pakistan
2Free Radical Research Laboratory, National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
3University medical health and Sciences, Skin Unit 11 Liaqat, Jamshoro, Pakistan
4Al-Mafraq Hospital, Dubai
Corresponding Author : Dr. Nasreen Thebo
Mycology Research laboratory Institute of Plant Sciences
University of Sindh, Jamshoro, Sindh, Pakistan
Tel: 0923332723518
E-mail: [email protected]
Received March 08, 2011; Accepted July 12, 2012; Published July 16, 2012
Citation: Thebo N, Sheikh W, Bhangar MI, Iqbal P, Nizamani MH (2012) Therapeutic and Antioxidant Potential in the Shell Extract of Prunus amygdalus against Dermal Mycosis. Med Aromat Plants 1:108. doi: 10.4172/2167-0412.1000108
Copyright: © 2012 Thebo N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Mycosis is a common harmful problem for health throughout the world. Ringworm infection is one of the most dermatomycoses caused by species of pathogenic fungi such as Epidermatophyton, Trichophyton and Microsporum. The potential of biotechnology is to provide health protection through medicinal plants because it also facilitates the earlier detection of various ailments by new biotechnological techniques. Almond posses a variety of benefical properties affecting most notably cancer, high blood pressure, infectious disease and diabetes. In our study, we have used first time Almond hard shell extract for the evolution of antioxidant, antimicrobial potential and therapeutic efficacy against dermatomycosis pathogenic fungi. The extract was prepared by soxhlet method and TPC in the extract was determined by spectrophotometerically. The antioxidant activity of crude extract of almond shell was evaluated by using DPPH (2-2-diphenyl-1-picryhydrazyl) and radical scavenging system. The Minimum Inhibition Concentration (MIC) of extract was determined by well method against isolated pathogenic causative organisms for confirmation. The possibility of short term therapy was only 15 days. The total antioxidant activity varied from 93.32 to 94.40% and total phenolic content was found 3.422 mg/gm in almond shell extract. Hard shell extract of almond was found to be most effective as an antifungal and antibacterial agent against human pathogenic. Finally the results provide a therapeutic potential for microbial infections.

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