alexa Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease | OMICS International | Abstract
ISSN: 2165-7831

Journal of Blood & Lymph
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Research Article

Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease

Destefani AC, Costa DS, Zanardo TEC and Taufner GH*

Department of Biotechnology, Federal University of Espírito Santo (UFES), Av. Marechal Campos 1468, Maruípe, CEP 29043-900, Vitória, ES, Brasil

*Corresponding Author:
Taufner GH
Biochemical Pharmacist
Department of Biotechnology
Federal University of Espírito Santo (UFES)
Av. Marechal Campos 1468, Maruípe
CEP 29043-900, Vitória, ES, Brasil
Tel: (27) 9 9890-9696
E-mail: [email protected]

Received Date: March 24, 2017; Accepted Date: April 19, 2017; Published Date: April 27, 2017

Citation: Destefani AC, Costa DS, Zanardo TEC, Taufner GH (2017) Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease. J Blood Lymph 7: 165. doi: 10.4172/2165-7831.1000165

Copyright: © 2017 Destefani AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Sickle cell disease (SCD) is an autosomal recessive inheritance disorder that affects the beta-globin gene and results in the replacement of the amino acid glutamic acid by valine in the β chain of the hemoglobin molecule, producing erythrocytes with defective forms and functions. A range of pathological conditions is associated with SCD, however, one in particular stands out by gravity. Acute thoracic syndrome (STA), characterized by the presence of pulmonary infiltrates associated with a clinical symptom such as chest pain, cough, wheezing, tachypnea and fever, is considered a leading cause of death in patients with sickle cell disease. Early diagnosis and introduction of an effective approach to complication are needed to improve outcomes and minimize associated morbidity and mortality.

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