alexa Therapeutic Effect of Amaranthus hybridus on Diabetic N
ISSN: 2329-6631

Journal of Developing Drugs
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Therapeutic Effect of Amaranthus hybridus on Diabetic Nephropathy

Balasubramanian T* and Karthikeyan M

Department of Pharmacology, Al Shifa College of Pharmacy, Kerala, India

*Corresponding Author:
Dr. Thirumalaiswamy Balasubramanian
Department of Pharmacology
Al Shifa College of Pharmacy
Poonthavanam Post, Kizhattur Village
Perinthalmanna, Malappuram Dist
Kerala-679 325, India
Tel: +919544496752
E-mail: [email protected]

Received date: December 29, 2015; Accepted date: January 07, 2016; Published date January 14, 2016

Citation: Balasubramanian T and Karthikeyan M (2016) Therapeutic Effect of Amaranthus hybridus on Diabetic Nephropathy. J Develop Drugs 5:147.doi:10.4172/2329-6631.1000147

Copyright: © 2016 Balasubramanian T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Amaranthus hybridus is claimed to be useful in treating dysentery, diarrhoea, hemorrhage of the bowel, ulcers, liver infections and knee pain in Indian traditional system of medicine, and in southern India, the leaves are used in folk medicine for the treatment of diabetes mellitus. The present research was conducted to evaluate the nephron protective effect of ethanol extract of Amaranthus hybridus leaves in Streptozotocin (STZ)-induced diabetic rats. Materials and methods: Wister albino rats were induced diabetic by a single dose of STZ (50 mg/kg i.p.). The serum and urine renal function parameters-creatinine, urea, uric acid, albumin and total proteins were measured on 15th day after daily oral administration of Amaranthus hybridus ethanolic leaves extract (AHELE) for 14 days at doses of 200 and 400 mg/kg. The antioxidant potential of extract was also determined. Hence, the effects of the AHELE treatments on the kidney histological profile in STZ nephrotoxic rats were observed. Results: The present study investigation showed that the AHELE significantly (P<0.001) attenuated elevations in the serum levels of creatinine, urea and uric acid, and urine levels of total proteins and albumin, in diabetic treated rats as compared with diabetic control rats. The extract also improved altered serum total protein associated with diabetes nephropathy. A significant decrease in TBARS (P<0.001), and significant increase in SOD (P<0.001), CAT (P<0.01) and reduced glutathione levels (P<0.001) were observed in the kidney of rats treated with AHELE. Furthermore, the histopathological study of kidney in drug treated rats shows significant protective effect against STZ oxidative stress. Conclusions: Our results suggest that Amaranthus hybridus possesses significant nephronprotective effect against oxidative damage in diabetic rats.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version